BRENDA - Enzyme Database
show all sequences of 1.1.1.315

Retinol dehydrogenases (RDHs) in the visual cycle

Parker, R.O.; Crouch, R.K.; Exp. Eye Res. 91, 788-792 (2010)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol-[retinal-binding-protein] + NAD+
Mus musculus
-
11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
eye
-
Mus musculus
-
retinal pigment epithelium
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
11-cis-retinol-[retinal-binding-protein] + NAD+
-
724922
Mus musculus
11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
RDH5
-
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol-[retinal-binding-protein] + NAD+
Mus musculus
-
11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
eye
-
Mus musculus
-
retinal pigment epithelium
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
11-cis-retinol-[retinal-binding-protein] + NAD+
-
724922
Mus musculus
11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
11-cis retinol oxidation occurs at a reduced rate in retinal pigment epithelium membranes from Rdh5-/- mice
Mus musculus
metabolism
RDH11, which can can utilize both cis and trans-retinoid substrates, plays a minor but complementary role to RDH5 in the flow of retinoids during dark adaptation
Mus musculus
physiological function
isomerization of 11-cis retinal to all-trans retinal in photoreceptors is the first step in vision. In the retinal pigment epithelium, all-trans retinol is converted to 11-cis retinol, and in the final enzymatic step, 11-cis-retinol is oxidized to 11-cis retinal, catalyzed by the enzyme RDH5. RDH5 does play a significant role in 11-cis retinol oxidation in the retinal pigment epithelium
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
11-cis retinol oxidation occurs at a reduced rate in retinal pigment epithelium membranes from Rdh5-/- mice
Mus musculus
metabolism
RDH11, which can can utilize both cis and trans-retinoid substrates, plays a minor but complementary role to RDH5 in the flow of retinoids during dark adaptation
Mus musculus
physiological function
isomerization of 11-cis retinal to all-trans retinal in photoreceptors is the first step in vision. In the retinal pigment epithelium, all-trans retinol is converted to 11-cis retinol, and in the final enzymatic step, 11-cis-retinol is oxidized to 11-cis retinal, catalyzed by the enzyme RDH5. RDH5 does play a significant role in 11-cis retinol oxidation in the retinal pigment epithelium
Mus musculus
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740740
Sahu
Conditional ablation of retino ...
Homo sapiens, Mus musculus
J. Biol. Chem.
290
27239-27247
2015
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3
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3
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1
1
-
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-
724922
Parker
Retinol dehydrogenases (RDHs) ...
Mus musculus
Exp. Eye Res.
91
788-792
2010
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3
3
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690842
Takahashi
Characterization of key residu ...
Homo sapiens
Biochem. J.
419
113-122
2009
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1
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13
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8
1
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692705
Farjo
RDH10 has 11-cis-retinol dehyd ...
Bos taurus, Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5089-5097
2009
1
-
1
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2
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2
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5
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1
1
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6
1
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1
1
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687735
Belyaeva
Kinetic analysis of human enzy ...
Homo sapiens
J. Biol. Chem.
283
20299-20308
2008
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1
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3
6
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1
1
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2
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1
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9
1
2
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3
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9
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1
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1
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1
9
1
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692332
Picozzi
Genomic organization and trans ...
Homo sapiens
FEBS Lett.
554
59-66
2003
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1
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9
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9
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715461
Wu
Mapping the ligand binding poc ...
Homo sapiens
J. Biol. Chem.
278
12390-12396
2003
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1
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1
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2
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1
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692700
Wu
Cloning and characterization o ...
Bos taurus, Homo sapiens, Mus musculus
Invest. Ophthalmol. Vis. Sci.
43
3365-3372
2002
-
-
3
-
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3
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2
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6
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9
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9
1
6
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12
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1
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3
12
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9
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9
1
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1
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715451
Chen
Interaction of 11-cis-retinol ...
Bos taurus
J. Biol. Chem.
276
21098-21104
2001
-
-
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1
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1
3
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1
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3
2
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1
1
-
-
-
715455
Liden
Biochemical defects in 11-cis- ...
Homo sapiens
J. Biol. Chem.
276
49251-49257
2001
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1
1
1
11
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1
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2
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2
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1
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11
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1
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716054
Huang
Modulation of the androgenic r ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
77
129-133
2001
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1
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1
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1
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690797
Wang
Activity of human 11-cis-retin ...
Homo sapiens
Biochem. J.
338
23-27
1999
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1
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3
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3
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45
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8
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2
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1
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49
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8
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715709
Simon
Intracellular localization and ...
Bos taurus
J. Cell Sci.
112
549-558
1999
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2
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1
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1
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1
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716292
Gonzalez-Fernandez
-
11-cis Retinol dehydrogenase m ...
Homo sapiens
Mol. Vis.
5
XI-XII
1999
-
1
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1
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716309
Yamamoto
Mutations in the gene encoding ...
Homo sapiens
Nat. Genet.
22
188-191
1999
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1
1
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2
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1
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1
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170681
Mata
Distribution of 11-cis LRAT, 1 ...
Bos taurus
Biochim. Biophys. Acta
1394
16-22
1998
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692942
Su
cDNA cloning, tissue distribut ...
Mus musculus
J. Biol. Chem.
273
17910-17916
1998
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692939
Chai
cDNA cloning and characterizat ...
Mus musculus
J. Biol. Chem.
272
33125-33131
1997
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1
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1
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5
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714012
Tsigelny
Structures important in NAD(P) ...
Bos taurus
Biochem. Biophys. Res. Commun.
226
118-127
1996
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715421
Simon
The retinal pigment epithelial ...
Bos taurus
J. Biol. Chem.
270
1107-1112
1995
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