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Literature summary for 1.1.1.315 extracted from

  • Wu, B.X.; Chen, Y.; Chen, Y.; Fan, J.; Rohrer, B.; Crouch, R.K.; Ma, J.X.
    Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE (2002), Invest. Ophthalmol. Vis. Sci., 43, 3365-3372.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Bos taurus
RDH10 is expressed in COS cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Mus musculus
-
-
microsome
-
Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38087
-
x * 38087, calculated from sequence Homo sapiens
38090
-
calculated from sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus Q8HZT6
-
-
Homo sapiens Q8IZV5
-
-
Mus musculus Q8VCH7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low activity Bos taurus
-
kidney low activity Bos taurus
-
liver low activity Bos taurus
-
lung low activity Bos taurus
-
pancreas low activity Bos taurus
-
retinal pigment epithelium
-
Homo sapiens
-
retinal pigment epithelium
-
Mus musculus
-
retinal pigment epithelium high activity Bos taurus
-
skeletal muscle low activity Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol + NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Homo sapiens all-trans-retinal + NADH + H+
-
r
all-trans-retinol + NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Mus musculus all-trans-retinal + NADH + H+
-
r
all-trans-retinol + NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Bos taurus all-trans-retinal + NADH + H+
-
r
all-trans-retinol + NADP+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Homo sapiens all-trans-retinal + NADPH + H+
-
r
all-trans-retinol + NADP+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Mus musculus all-trans-retinal + NADPH + H+
-
r
all-trans-retinol + NADP+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 Bos taurus all-trans-retinal + NADPH + H+
-
r
additional information RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 Homo sapiens ?
-
?
additional information RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 Mus musculus ?
-
?
additional information RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 Bos taurus ?
-
?

Subunits

Subunits Comment Organism
? x * 38087, calculated from sequence Homo sapiens

Synonyms

Synonyms Comment Organism
atRDH
-
Homo sapiens
atRDH
-
Mus musculus
atRDH
-
Bos taurus
RDH10
-
Homo sapiens
RDH10
-
Mus musculus
RDH10
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor Mus musculus
NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor Bos taurus
NAD+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor Homo sapiens
NADH
-
Homo sapiens
NADH
-
Mus musculus
NADH
-
Bos taurus
NADP+ the addition of NADP+ resulted in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor Homo sapiens
NADP+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor Mus musculus
NADP+ the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
NADPH
-
Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens calculated from sequence
-
7.4