BRENDA - Enzyme Database
show all sequences of 1.1.1.315

Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE

Wu, B.X.; Chen, Y.; Chen, Y.; Fan, J.; Rohrer, B.; Crouch, R.K.; Ma, J.X.; Invest. Ophthalmol. Vis. Sci. 43, 3365-3372 (2002)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
-
Bos taurus
-
Mus musculus
RDH10 is expressed in COS cells
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Bos taurus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Mus musculus
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38087
-
x * 38087, calculated from sequence
Homo sapiens
38090
-
calculated from sequence
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
Q8HZT6
-
-
Homo sapiens
Q8IZV5
-
-
Mus musculus
Q8VCH7
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
low activity
Bos taurus
-
kidney
low activity
Bos taurus
-
liver
low activity
Bos taurus
-
lung
low activity
Bos taurus
-
pancreas
low activity
Bos taurus
-
retinal pigment epithelium
-
Mus musculus
-
retinal pigment epithelium
high activity
Bos taurus
-
retinal pigment epithelium
-
Homo sapiens
-
skeletal muscle
low activity
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Homo sapiens
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Mus musculus
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Bos taurus
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Homo sapiens
all-trans-retinal + NADPH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Mus musculus
all-trans-retinal + NADPH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Bos taurus
all-trans-retinal + NADPH + H+
-
-
-
r
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Homo sapiens
?
-
-
-
-
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Mus musculus
?
-
-
-
-
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Bos taurus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 38087, calculated from sequence
Homo sapiens
Synonyms
Synonyms
Commentary
Organism
atRDH
-
Bos taurus
atRDH
-
Homo sapiens
atRDH
-
Mus musculus
RDH10
-
Bos taurus
RDH10
-
Homo sapiens
RDH10
-
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Bos taurus
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor
Homo sapiens
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Mus musculus
NADH
-
Homo sapiens
NADH
-
Bos taurus
NADH
-
Mus musculus
NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Bos taurus
NADP+
the addition of NADP+ resulted in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor
Homo sapiens
NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Mus musculus
NADPH
-
Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from sequence
-
7.4
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Bos taurus
-
Mus musculus
RDH10 is expressed in COS cells
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Bos taurus
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor
Homo sapiens
NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Mus musculus
NADH
-
Homo sapiens
NADH
-
Bos taurus
NADH
-
Mus musculus
NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Bos taurus
NADP+
the addition of NADP+ resulted in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor
Homo sapiens
NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor
Mus musculus
NADPH
-
Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Bos taurus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Mus musculus
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38087
-
x * 38087, calculated from sequence
Homo sapiens
38090
-
calculated from sequence
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
low activity
Bos taurus
-
kidney
low activity
Bos taurus
-
liver
low activity
Bos taurus
-
lung
low activity
Bos taurus
-
pancreas
low activity
Bos taurus
-
retinal pigment epithelium
high activity
Bos taurus
-
retinal pigment epithelium
-
Homo sapiens
-
retinal pigment epithelium
-
Mus musculus
-
skeletal muscle
low activity
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Homo sapiens
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Mus musculus
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NAD+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Bos taurus
all-trans-retinal + NADH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Homo sapiens
all-trans-retinal + NADPH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Mus musculus
all-trans-retinal + NADPH + H+
-
-
-
r
all-trans-retinol + NADP+
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10
692700
Bos taurus
all-trans-retinal + NADPH + H+
-
-
-
r
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Homo sapiens
?
-
-
-
-
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Mus musculus
?
-
-
-
-
additional information
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10
692700
Bos taurus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 38087, calculated from sequence
Homo sapiens
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from sequence
-
7.4
Other publictions for EC 1.1.1.315
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740740
Sahu
Conditional ablation of retino ...
Homo sapiens, Mus musculus
J. Biol. Chem.
290
27239-27247
2015
-
-
2
-
-
-
-
-
-
-
-
-
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2
-
-
-
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-
-
3
-
3
-
2
-
-
-
-
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724922
Parker
Retinol dehydrogenases (RDHs) ...
Mus musculus
Exp. Eye Res.
91
788-792
2010
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
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1
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-
-
1
-
-
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1
-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
690842
Takahashi
Characterization of key residu ...
Homo sapiens
Biochem. J.
419
113-122
2009
-
-
1
-
13
-
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
4
-
-
-
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-
1
4
-
13
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692705
Farjo
RDH10 has 11-cis-retinol dehyd ...
Bos taurus, Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5089-5097
2009
1
-
1
-
-
-
-
2
-
-
-
2
-
5
-
-
-
-
-
1
1
-
6
1
4
-
-
-
-
-
-
-
2
-
-
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
1
1
-
6
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
687735
Belyaeva
Kinetic analysis of human enzy ...
Homo sapiens
J. Biol. Chem.
283
20299-20308
2008
-
-
1
-
-
-
3
6
-
-
1
1
-
2
-
-
1
-
-
-
-
1
9
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
2
3
-
-
-
-
3
-
9
-
-
1
1
-
-
-
1
-
-
-
1
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692332
Picozzi
Genomic organization and trans ...
Homo sapiens
FEBS Lett.
554
59-66
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
9
-
-
-
-
2
-
-
-
-
-
-
-
-
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-
-
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-
-
-
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-
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-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715461
Wu
Mapping the ligand binding poc ...
Homo sapiens
J. Biol. Chem.
278
12390-12396
2003
-
-
1
-
-
-
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1
-
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2
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1
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1
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1
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1
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-
-
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-
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-
-
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-
692700
Wu
Cloning and characterization o ...
Bos taurus, Homo sapiens, Mus musculus
Invest. Ophthalmol. Vis. Sci.
43
3365-3372
2002
-
-
3
-
-
-
-
-
3
-
2
-
-
6
-
-
-
-
-
9
-
-
9
1
6
-
-
-
-
-
-
-
12
-
1
-
-
-
3
12
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
9
-
-
9
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
715451
Chen
Interaction of 11-cis-retinol ...
Bos taurus
J. Biol. Chem.
276
21098-21104
2001
-
-
-
-
-
-
-
-
1
-
1
3
-
2
-
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1
-
-
2
-
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3
2
1
-
-
-
-
-
-
-
2
-
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-
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-
-
2
-
-
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-
-
-
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1
-
1
3
-
-
-
1
-
2
-
-
3
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
715455
Liden
Biochemical defects in 11-cis- ...
Homo sapiens
J. Biol. Chem.
276
49251-49257
2001
-
1
1
1
11
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
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-
1
1
-
1
11
-
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1
-
2
-
-
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-
-
-
-
-
-
1
-
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-
-
-
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-
-
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-
-
-
716054
Huang
Modulation of the androgenic r ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
77
129-133
2001
-
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1
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-
-
-
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1
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1
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1
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1
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1
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-
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-
-
-
-
-
690797
Wang
Activity of human 11-cis-retin ...
Homo sapiens
Biochem. J.
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716292
Gonzalez-Fernandez
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11-cis Retinol dehydrogenase m ...
Homo sapiens
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1999
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716309
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Mutations in the gene encoding ...
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1999
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170681
Mata
Distribution of 11-cis LRAT, 1 ...
Bos taurus
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1998
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cDNA cloning, tissue distribut ...
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cDNA cloning and characterizat ...
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Tsigelny
Structures important in NAD(P) ...
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1996
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The retinal pigment epithelial ...
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