BRENDA - Enzyme Database
show all sequences of 1.1.1.315

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.

Wang, J.; Chai, X.; Eriksson, U.; Napoli, J.L.; Biochem. J. 338, 23-27 (1999)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in CHO cells; expression in CHO-K1 cells
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0063
-
11-cis-retinol
pH 8, 37°C
Homo sapiens
0.0063
-
11-cis-retinol-[cellular retinaldehyde binding protein]
pH 8.0, 37°C
Homo sapiens
0.0066
-
9-cis-retinol
pH 8, 37°C
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol + NAD+
Homo sapiens
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium
11-cis-retinal + NADH
-
-
?
9-cis-retinol + NAD+
Homo sapiens
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism
9-cis-retinal + NADH
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Homo sapiens
Q92781
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
17% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
amygdala
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
aorta
26% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
bladder
29% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
bone marrow
11% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
brain
8% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
caudate nucleus
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
caudate putamen
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
cerebellum
6% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
cerebral cortex
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
colon
45% mRNA expression of Rdh5 compared to liver; 45% of the expression in liver
Homo sapiens
-
fetus
fetal brain (5% mRNA expression of Rdh5 compared to adult liver), fetal heart (6% mRNA expression of Rdh5 compared to adultliver), fetal kidney (17% mRNA expression of Rdh5 compared to adult liver), fetal liver (20% mRNA expression of Rdh5 compared to adult liver), fetal spleen (5% mRNA expression of Rdh5 compared to adult liver), fetal thymus (7% mRNA expression of Rdh5 compared to adult liver), fetal lung (14% mRNA expression of Rdh5 compared to liver)
Homo sapiens
-
frontal lobe
3% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
heart
26% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
hippocampus
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
kidney
37% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
leukocyte
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
liver
highest expression among extra-ocular tissues tested; high mRNA expression of Rdh5
Homo sapiens
-
lung
10% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
lymph node
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
mammary gland
97% mRNA expression of Rdh5 compared to liver; 97% of the expression in liver
Homo sapiens
-
medulla oblongata
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
additional information
mRNA expression is widespread in extra-ocular tissues with human liver and mammary gland showing the most intense signals
Homo sapiens
-
occipital lobe
8% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
ovary
25% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
pancreas
28% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
pituitary gland
20% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
placenta
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
prostate gland
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
salivary gland
10% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
skeletal muscle
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
small intestine
39% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
spinal cord
24% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
spleen
28% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
stomach
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
substantia nigra
11% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
subthalamic nucleus
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
temporal lobe
6% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
testis
22% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
thalamus
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
thymus
43% mRNA expression of Rdh5 compared to liver; 43% of the expression in liver
Homo sapiens
-
thyroid gland
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
trachea
17% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
uterus
25% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
vermiform appendix
24% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
11-cis-retinol + NAD+
-
690797
Homo sapiens
11-cis-retinal + NADH
-
-
-
?
11-cis-retinol + NAD+
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium
690797
Homo sapiens
11-cis-retinal + NADH
-
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
-
690797
Homo sapiens
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
-
?
13-cis-retinol + NAD+
-
690797
Homo sapiens
13-cis-retinal + NADH
-
-
-
?
9-cis-retinol + NAD+
-
690797
Homo sapiens
9-cis-retinal + NADH
-
-
-
?
9-cis-retinol + NAD+
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism
690797
Homo sapiens
9-cis-retinal + NADH
-
-
-
?
additional information
no significant activity with all-trans-retinol. Rdh5 recognizes 5alpha-androstan-3alpha,17beta-diol (3alpha-adiol) and androsterone as substrates
690797
Homo sapiens
?
-
-
-
-
additional information
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism and recognizes 5alpha-androstan-3alpha,17beta-diol and androsterone as substrates, i.e. 3alpha-hydroxysteroid dehydrogenase activity, but not testosterone, dihydrotestosterone, oestradiol and corticosterone
690797
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
11-cis-retinol dehydrogenase
-
Homo sapiens
RDH5
-
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in CHO cells
Homo sapiens
expression in CHO-K1 cells
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0063
-
11-cis-retinol
pH 8, 37°C
Homo sapiens
0.0063
-
11-cis-retinol-[cellular retinaldehyde binding protein]
pH 8.0, 37°C
Homo sapiens
0.0066
-
9-cis-retinol
pH 8, 37°C
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol + NAD+
Homo sapiens
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium
11-cis-retinal + NADH
-
-
?
9-cis-retinol + NAD+
Homo sapiens
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism
9-cis-retinal + NADH
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
17% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
amygdala
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
aorta
26% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
bladder
29% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
bone marrow
11% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
brain
8% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
caudate nucleus
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
caudate putamen
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
cerebellum
6% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
cerebral cortex
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
colon
45% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
colon
45% of the expression in liver
Homo sapiens
-
fetus
fetal brain (5% mRNA expression of Rdh5 compared to adult liver), fetal heart (6% mRNA expression of Rdh5 compared to adultliver), fetal kidney (17% mRNA expression of Rdh5 compared to adult liver), fetal liver (20% mRNA expression of Rdh5 compared to adult liver), fetal spleen (5% mRNA expression of Rdh5 compared to adult liver), fetal thymus (7% mRNA expression of Rdh5 compared to adult liver), fetal lung (14% mRNA expression of Rdh5 compared to liver)
Homo sapiens
-
frontal lobe
3% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
heart
26% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
hippocampus
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
kidney
37% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
leukocyte
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
liver
high mRNA expression of Rdh5
Homo sapiens
-
liver
highest expression among extra-ocular tissues tested
Homo sapiens
-
lung
10% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
lymph node
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
mammary gland
97% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
mammary gland
97% of the expression in liver
Homo sapiens
-
medulla oblongata
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
additional information
mRNA expression is widespread in extra-ocular tissues with human liver and mammary gland showing the most intense signals
Homo sapiens
-
occipital lobe
8% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
ovary
25% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
pancreas
28% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
pituitary gland
20% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
placenta
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
prostate gland
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
salivary gland
10% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
skeletal muscle
5% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
small intestine
39% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
spinal cord
24% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
spleen
28% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
stomach
21% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
substantia nigra
11% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
subthalamic nucleus
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
temporal lobe
6% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
testis
22% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
thalamus
7% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
thymus
43% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
thymus
43% of the expression in liver
Homo sapiens
-
thyroid gland
9% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
trachea
17% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
uterus
25% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
vermiform appendix
24% mRNA expression of Rdh5 compared to liver
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
11-cis-retinol + NAD+
-
690797
Homo sapiens
11-cis-retinal + NADH
-
-
-
?
11-cis-retinol + NAD+
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium
690797
Homo sapiens
11-cis-retinal + NADH
-
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
-
690797
Homo sapiens
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
-
?
13-cis-retinol + NAD+
-
690797
Homo sapiens
13-cis-retinal + NADH
-
-
-
?
9-cis-retinol + NAD+
-
690797
Homo sapiens
9-cis-retinal + NADH
-
-
-
?
9-cis-retinol + NAD+
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism
690797
Homo sapiens
9-cis-retinal + NADH
-
-
-
?
additional information
no significant activity with all-trans-retinol. Rdh5 recognizes 5alpha-androstan-3alpha,17beta-diol (3alpha-adiol) and androsterone as substrates
690797
Homo sapiens
?
-
-
-
-
additional information
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism and recognizes 5alpha-androstan-3alpha,17beta-diol and androsterone as substrates, i.e. 3alpha-hydroxysteroid dehydrogenase activity, but not testosterone, dihydrotestosterone, oestradiol and corticosterone
690797
Homo sapiens
?
-
-
-
-
Other publictions for EC 1.1.1.315
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740740
Sahu
Conditional ablation of retino ...
Homo sapiens, Mus musculus
J. Biol. Chem.
290
27239-27247
2015
-
-
2
-
-
-
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-
-
-
-
-
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2
-
-
-
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-
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3
-
3
-
2
-
-
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4
-
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-
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2
4
-
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-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724922
Parker
Retinol dehydrogenases (RDHs) ...
Mus musculus
Exp. Eye Res.
91
788-792
2010
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
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2
-
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1
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1
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1
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1
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1
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2
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1
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-
-
-
-
-
-
-
3
3
-
-
-
690842
Takahashi
Characterization of key residu ...
Homo sapiens
Biochem. J.
419
113-122
2009
-
-
1
-
13
-
-
8
1
-
-
-
-
1
-
-
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-
-
-
2
-
2
-
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4
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1
4
-
13
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8
1
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2
-
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-
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-
-
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-
692705
Farjo
RDH10 has 11-cis-retinol dehyd ...
Bos taurus, Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5089-5097
2009
1
-
1
-
-
-
-
2
-
-
-
2
-
5
-
-
-
-
-
1
1
-
6
1
4
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2
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1
-
1
2
-
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2
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-
-
2
-
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-
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1
1
-
6
1
-
-
-
-
-
-
-
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-
1
1
-
-
-
687735
Belyaeva
Kinetic analysis of human enzy ...
Homo sapiens
J. Biol. Chem.
283
20299-20308
2008
-
-
1
-
-
-
3
6
-
-
1
1
-
2
-
-
1
-
-
-
-
1
9
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
2
3
-
-
-
-
3
-
9
-
-
1
1
-
-
-
1
-
-
-
1
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692332
Picozzi
Genomic organization and trans ...
Homo sapiens
FEBS Lett.
554
59-66
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
9
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715461
Wu
Mapping the ligand binding poc ...
Homo sapiens
J. Biol. Chem.
278
12390-12396
2003
-
-
1
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1
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2
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1
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1
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1
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1
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-
-
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-
692700
Wu
Cloning and characterization o ...
Bos taurus, Homo sapiens, Mus musculus
Invest. Ophthalmol. Vis. Sci.
43
3365-3372
2002
-
-
3
-
-
-
-
-
3
-
2
-
-
6
-
-
-
-
-
9
-
-
9
1
6
-
-
-
-
-
-
-
12
-
1
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-
3
12
-
-
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3
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2
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1
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3
2
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Biochemical defects in 11-cis- ...
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1
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1
1
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1
11
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1
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45
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8
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2
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1
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3
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8
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1
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716292
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11-cis Retinol dehydrogenase m ...
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Yamamoto
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1
1
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1
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1
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2
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170681
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4
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1
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6
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5
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Tsigelny
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1
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