BRENDA - Enzyme Database
show all sequences of 1.1.1.315

Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin

Chen, P.; Lee, T.D.; Fong, H.K.; J. Biol. Chem. 276, 21098-21104 (2001)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Bos taurus
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
32000
-
x * 32000, SDS-PAGE
Bos taurus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+
Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
-
?
additional information
Bos taurus
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
enzyme copurifies with retinal G protein coupled receptor from microsomes
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
retina
-
Bos taurus
-
retinal pigment epithelium
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
-
715451
Bos taurus
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+
-
715451
Bos taurus
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
-
-
?
additional information
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR
715451
Bos taurus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 32000, SDS-PAGE
Bos taurus
More
enzyme copurifies with retinal G protein coupled receptor from microsomes
Bos taurus
Synonyms
Synonyms
Commentary
Organism
cRDH
-
Bos taurus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
NAD+ is preferred over NADP+
Bos taurus
NADP+
NAD+ is preferred over NADP+
Bos taurus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
NAD+ is preferred over NADP+
Bos taurus
NADP+
NAD+ is preferred over NADP+
Bos taurus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Bos taurus
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
32000
-
x * 32000, SDS-PAGE
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+
Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
-
?
additional information
Bos taurus
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
enzyme copurifies with retinal G protein coupled receptor from microsomes
Bos taurus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
retina
-
Bos taurus
-
retinal pigment epithelium
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
-
715451
Bos taurus
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
-
-
?
11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+
-
715451
Bos taurus
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
-
-
?
additional information
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR
715451
Bos taurus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 32000, SDS-PAGE
Bos taurus
More
enzyme copurifies with retinal G protein coupled receptor from microsomes
Bos taurus
General Information
General Information
Commentary
Organism
physiological function
cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle
Bos taurus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle
Bos taurus
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740740
Sahu
Conditional ablation of retino ...
Homo sapiens, Mus musculus
J. Biol. Chem.
290
27239-27247
2015
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2
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2
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3
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4
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2
4
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-
3
-
3
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-
-
-
-
-
-
-
-
1
1
-
-
-
724922
Parker
Retinol dehydrogenases (RDHs) ...
Mus musculus
Exp. Eye Res.
91
788-792
2010
-
-
-
-
-
-
-
-
-
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1
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1
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2
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1
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1
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1
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1
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1
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2
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1
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3
3
-
-
-
690842
Takahashi
Characterization of key residu ...
Homo sapiens
Biochem. J.
419
113-122
2009
-
-
1
-
13
-
-
8
1
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1
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2
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2
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4
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1
4
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13
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8
1
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2
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-
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-
-
-
-
692705
Farjo
RDH10 has 11-cis-retinol dehyd ...
Bos taurus, Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5089-5097
2009
1
-
1
-
-
-
-
2
-
-
-
2
-
5
-
-
-
-
-
1
1
-
6
1
4
-
-
-
-
-
-
-
2
-
-
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
1
1
-
6
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
687735
Belyaeva
Kinetic analysis of human enzy ...
Homo sapiens
J. Biol. Chem.
283
20299-20308
2008
-
-
1
-
-
-
3
6
-
-
1
1
-
2
-
-
1
-
-
-
-
1
9
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
2
3
-
-
-
-
3
-
9
-
-
1
1
-
-
-
1
-
-
-
1
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692332
Picozzi
Genomic organization and trans ...
Homo sapiens
FEBS Lett.
554
59-66
2003
-
-
-
-
-
-
-
-
-
-
-
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1
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-
9
-
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2
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-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715461
Wu
Mapping the ligand binding poc ...
Homo sapiens
J. Biol. Chem.
278
12390-12396
2003
-
-
1
-
-
-
-
1
-
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2
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1
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1
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1
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-
1
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-
-
-
-
-
-
-
692700
Wu
Cloning and characterization o ...
Bos taurus, Homo sapiens, Mus musculus
Invest. Ophthalmol. Vis. Sci.
43
3365-3372
2002
-
-
3
-
-
-
-
-
3
-
2
-
-
6
-
-
-
-
-
9
-
-
9
1
6
-
-
-
-
-
-
-
12
-
1
-
-
-
3
12
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
9
-
-
9
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
715451
Chen
Interaction of 11-cis-retinol ...
Bos taurus
J. Biol. Chem.
276
21098-21104
2001
-
-
-
-
-
-
-
-
1
-
1
3
-
2
-
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1
-
-
2
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3
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
1
3
-
-
-
1
-
2
-
-
3
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
715455
Liden
Biochemical defects in 11-cis- ...
Homo sapiens
J. Biol. Chem.
276
49251-49257
2001
-
1
1
1
11
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
11
-
-
-
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1
-
2
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716054
Huang
Modulation of the androgenic r ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
77
129-133
2001
-
-
1
-
-
-
-
-
-
-
-
-
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1
-
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1
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1
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1
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1
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-
690797
Wang
Activity of human 11-cis-retin ...
Homo sapiens
Biochem. J.
338
23-27
1999
-
-
1
-
-
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-
3
-
-
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2
-
3
-
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-
45
-
-
8
-
2
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1
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2
1
-
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3
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2
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-
49
-
-
8
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
715709
Simon
Intracellular localization and ...
Bos taurus
J. Cell Sci.
112
549-558
1999
-
-
-
-
2
-
-
-
1
-
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1
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1
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1
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1
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-
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-
-
-
716292
Gonzalez-Fernandez
-
11-cis Retinol dehydrogenase m ...
Homo sapiens
Mol. Vis.
5
XI-XII
1999
-
1
-
-
-
-
-
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1
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1
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716309
Yamamoto
Mutations in the gene encoding ...
Homo sapiens
Nat. Genet.
22
188-191
1999
-
1
1
-
2
-
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1
-
-
-
-
-
1
-
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1
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2
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1
1
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1
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1
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170681
Mata
Distribution of 11-cis LRAT, 1 ...
Bos taurus
Biochim. Biophys. Acta
1394
16-22
1998
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4
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2
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2
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1
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4
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2
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692942
Su
cDNA cloning, tissue distribut ...
Mus musculus
J. Biol. Chem.
273
17910-17916
1998
-
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1
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1
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2
-
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-
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2
-
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6
-
2
-
-
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-
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2
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1
2
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1
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2
-
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6
-
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-
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-
-
-
692939
Chai
cDNA cloning and characterizat ...
Mus musculus
J. Biol. Chem.
272
33125-33131
1997
-
-
1
-
-
-
1
1
-
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-
1
-
2
-
-
-
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-
5
-
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3
-
2
-
-
-
-
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1
-
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-
-
-
1
1
-
-
-
-
1
-
1
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-
-
1
-
-
-
-
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5
-
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3
-
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-
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-
-
-
-
-
-
-
-
714012
Tsigelny
Structures important in NAD(P) ...
Bos taurus
Biochem. Biophys. Res. Commun.
226
118-127
1996
-
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1
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1
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1
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1
1
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-
715421
Simon
The retinal pigment epithelial ...
Bos taurus
J. Biol. Chem.
270
1107-1112
1995
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1
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1
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1
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1
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1
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1
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1
2
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2
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