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Literature summary for 1.1.1.300 extracted from
- Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Mueller glial cells (2019), Neuron, 102, 1172-1183.e5 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Rdh10, recombinant enzyme expression in HEK-293T cells, coexpression with with bovine RGR | Homo sapiens |
| gene Rdh10, recombinant enzyme expression in HEK-293T cells, coexpression with with bovine RGR | Mus musculus |
| gene Rdh10, recombinant enzyme expression in HEK-293T cells, coexpression with with bovine RGR | Gallus gallus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation and analysis of RGR knockout mouse microsomes | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Gallus gallus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinol + NADP+ | Homo sapiens | - |
retinal + NADPH + H+ | - |
? |  |
| retinol + NADP+ | Mus musculus | - |
retinal + NADPH + H+ | - |
? | |
| retinol + NADP+ | Gallus gallus | - |
retinal + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | A0A3Q3ATC8 | - |
- |
| Homo sapiens | Q8IZV5 | - |
- |
| Mus musculus | Q8VCH7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | - |
Homo sapiens | - |
| eye | - |
Mus musculus | - |
| eye | - |
Gallus gallus | - |
| Mueller cell | - |
Homo sapiens | - |
| Mueller cell | - |
Mus musculus | - |
| Mueller cell | - |
Gallus gallus | - |
| retina | - |
Homo sapiens | - |
| retina | - |
Mus musculus | - |
| retina | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinol + NADP+ | - |
Homo sapiens | retinal + NADPH + H+ | - |
? | |
| retinol + NADP+ | - |
Mus musculus | retinal + NADPH + H+ | - |
? | |
| retinol + NADP+ | - |
Gallus gallus | retinal + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RDH10 | - |
Homo sapiens |
| RDH10 | - |
Mus musculus |
| RDH10 | - |
Gallus gallus |
| retinol dehydrogenase-10 | - |
Homo sapiens |
| retinol dehydrogenase-10 | - |
Mus musculus |
| retinol dehydrogenase-10 | - |
Gallus gallus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
in vivo assay at | Homo sapiens |
| 37 | - |
in vivo assay at | Mus musculus |
| 37 | - |
in vivo assay at | Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Mus musculus | |
| NADP+ | - |
Gallus gallus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
| NADPH | - |
Gallus gallus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | isolated retinas from Rgr+/+ and Rgr-/- mice are exposed to continuous light, and cone photoresponses are recorded. Cones in Rgr-/- retinas lose sensitivity at a faster rate than cones in Rgr+/+ retinas | Homo sapiens |
| malfunction | isolated retinas from Rgr+/+ and Rgr-/- mice are exposed to continuous light, and cone photoresponses are recorded. Cones in Rgr-/- retinas lose sensitivity at a faster rate than cones in Rgr+/+ retinas | Gallus gallus |
| malfunction | isolated retinas from Rgr+/+ and Rgr-/- mice are exposed to continuous light, and cone photoresponses are recorded. Cones in Rgr-/- retinas lose sensitivity at a significantly faster rate than cones in Rgr+/+ retinas. A similar effect is seen in Rgr+/+ retinas following treatment with alpha-aminoadipic acid. These results indicate that maintenance and recovery of cone sensitivity in isolated mouse retinas requires a light-driven visual cycle that depends on RGR opsin. Thus, ciliary photoreceptors of vertebrates, like the rhabdomeric photoreceptors of invertebrates, can use light itself to regenerate visual pigment | Mus musculus |
| physiological function | the retinal RPE G-protein-coupled receptor, RGR opsin, and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. RGR opsin is a non-visual opsin in intracellular membranes of RPE and Müller cells. The interaction between RGR and Rdh10 is specific. RGR opsin is a critical component of the Müller-cell visual cycle, and that regeneration of cone visual pigment can be driven by light, role of RGR opsin in the regeneration of cone visual pigment. Cones are responsible for vision in bright light and operate at high rates of opsin photoisomerization. Recovery of cone sensitivity is shown to be limited by chromophore supply. Only 11-cis-retinal (11cRAL) can regenerate bleached opsin. Coupled photoisomerization and oxidoreduction of vitamin A by RGR opsin and Rdh10, overview | Homo sapiens |
| physiological function | the retinal RPE G-protein-coupled receptor, RGR opsin, and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. RGR opsin is a non-visual opsin in intracellular membranes of RPE and Müller cells. The interaction between RGR and Rdh10 is specific. RGR opsin is a critical component of the Müller-cell visual cycle, and that regeneration of cone visual pigment can be driven by light, role of RGR opsin in the regeneration of cone visual pigment. Cones are responsible for vision in bright light and operate at high rates of opsin photoisomerization. Recovery of cone sensitivity is shown to be limited by chromophore supply. Only 11-cis-retinal (11cRAL) can regenerate bleached opsin. Coupled photoisomerization and oxidoreduction of vitamin A by RGR opsin and Rdh10, overview | Mus musculus |
| physiological function | the retinal RPE G-protein-coupled receptor, RGR opsin, and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. RGR opsin is a non-visual opsin in intracellular membranes of RPE and Müller cells. The interaction between RGR and Rdh10 is specific. RGR opsin is a critical component of the Müller-cell visual cycle, and that regeneration of cone visual pigment can be driven by light, role of RGR opsin in the regeneration of cone visual pigment. Cones are responsible for vision in bright light and operate at high rates of opsin photoisomerization. Recovery of cone sensitivity is shown to be limited by chromophore supply. Only 11-cis-retinal (11cRAL) can regenerate bleached opsin. Coupled photoisomerization and oxidoreduction of vitamin A by RGR opsin and Rdh10, overview | Gallus gallus |
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