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Literature summary for 1.1.1.300 extracted from

  • Xue, Y.; Sato, S.; Razafsky, D.; Sahu, B.; Shen, S.Q.; Potter, C.; Sandell, L.L.; Corbo, J.C.; Palczewski, K.; Maeda, A.; Hodzic, D.; Kefalov, V.J.
    The role of retinol dehydrogenase 10 in the cone visual cycle (2017), Sci. Rep., 7, 2390 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.300

Protein Variants

Protein Variants Comment Organism
additional information RDH10 enzyme knockout and overexpression in retina cell. Rdh10 mRNA levels are substantially reduced in retinas obtained from Pdgfra-Cre Rdh10flox/flox mice through a knockout in Müller cells. Similarly, the expression of Rdh10 is also dramatically reduced in Six3-Cre Rdh10flox/flox retinas, demonstrating its suppression in the entire retina. In contrast, Rdh10 mRNA levels are notably increased in transgenic Rdh10+ mice. The deletion of RDH10 in cones does not affect the overall number of cone cells or their function, and cone dark adaptation in vivo is unaffected by cone-specific deletion of RDH10 Mus musculus
additional information generation of mice lacking RDH10 either in cone photoreceptors, Müller cells, or the entire retina. In vivo electroretinography and transretinal recordings reveal normal cone photoresponses in all RDH10-deficient mouse lines. Notably, their cone-driven dark adaptation both in vivo and in isolated retina is unaffected, indicating that RDH10 is not required for the function of the retina visual cycle. Generation of transgenic mice expressing RDH10 ectopically in rod cells. Rod dark adaptation is unaffected by the expression of RDH10 and transgenic rods are unable to use cis-retinol for pigment regeneration. Lack of phenotype of mice lacking RDH10 in the entire retina Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NADPH + H+ Mus musculus
-
 all-trans-retinol + NADP+
-
 ?
retinol + NADP+ Mus musculus
-
 retinal + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCH7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Mus musculus
-
Mueller cell
-
 Mus musculus
-
Mueller cell the enzyme is expressed abundantly in Mueller cells Mus musculus
-
retina
-
 Mus musculus
-
retina RDH10 is upregulated in rod/cone hybrid retinas Mus musculus
-
retinal cone
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + NADPH + H+
-
 Mus musculus all-trans-retinol + NADP+
-
 ?
retinol + NADP+
-
 Mus musculus retinal + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
RDH10
-
 Mus musculus
retinol dehydrogenase 10
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mus musculus
NADPH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking RDH10 either in cone photoreceptors, Müller cells, or the entire retina show normal cone photoresponses in all RDH10-deficient mouse lines. Their cone-driven dark adaptation both in vivo and in isolated retina is unaffected, indicating that RDH10 is not required for the function of the retina visual cycle. In transgenic mice overexpressing RDH10 ectopically in rod cells, rod dark adaptation is unaffected and transgenic rods are unable to use cis-retinol for pigment regeneration Mus musculus
malfunction RDH10 is not required for the function of the retina visual cycle. Transgenic mice expressing RDH10 ectopically in rod cells show, that rod dark adaptation is unaffected by the expression of RDH10 and transgenic rods are unable to use cis-retinol for pigment regeneration. Lack of phenotype of mice lacking RDH10 in the entire retina Mus musculus
physiological function pigment regeneration is critical for the function of cone photoreceptors in bright and rapidly-changing light conditions. This process is facilitated by the recently-characterized retina visual cycle, in which Müller cells recycle spent all-trans-retinol visual chromophore back to 11-cis-retinol. This 11-cis-retinol is oxidized selectively in cones to the 11-cis-retinal used for pigment regeneration. Retinol dehydrogenase 10 (RDH10) is responsible for the oxidation of 11-cis-retinol in the cone visual cycle, but RDH10 is not the dominant retina 11-cis-RDH, overview. Cone RDH10 is not required for normal cone dark adaptation Mus musculus
physiological function cone-specific 11-cis-RDH is likely to be important in regulating access to the retina visual cycle. Retinol dehydrogenase 10, RDH10 (UniProt ID Q8VCH7), is not the dominant retina 11-cis-RDH. Cone RDH10 is not required for the normal function of dark-adapted cones and for normal cone dark adaptation, as well as for the retina visual cycle Mus musculus