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Literature summary for 1.1.1.300 extracted from

  • Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kim, T.; Nelson, P.S.; Kedishvili, N.Y.
    Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids (2005), Biochemistry, 44, 7035-7047.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
11-cis-retinal pH 7.4, 37°C Homo sapiens
0.00014
-
9-cis-retinal pH 7.4, 37°C Homo sapiens
0.0004
-
all-trans-retinal
-
Homo sapiens
0.00074
-
NADPH pH 7.4, 37°C Homo sapiens
0.0012
-
NADPH pH 7.4, 37°C Homo sapiens
0.0012
-
NADP+ pH 7.4, 37°C Homo sapiens
0.0016
-
11-cis-retinol pH 7.4, 37°C Homo sapiens
0.0016
-
9-cis-retinol pH 7.4, 37°C Homo sapiens
0.0032
-
NADP+ pH 7.4, 37°C Homo sapiens
0.004
-
all-trans-retinol pH 7.4, 37°C Homo sapiens
2.22
-
NADH pH 7.4, 37°C Homo sapiens
2.42
-
NADH pH 7.4, 37°C Homo sapiens
7.75
-
NAD+ pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
365000
-
molecular mass of RDH12-His6 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-cis-retinal + NADPH + H+ Homo sapiens
-
11-cis-retinol + NADP+
-
r
all-trans retinal + NADPH + H+ Homo sapiens
-
all-tans-retinol + NADP+
-
r
n-nonanal + NADPH + H+ Homo sapiens might play a role in detoxification of lipid peroxidation products n-nonanol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q96NR8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-cis-retinal + NADH + H+ NADH much less efficient than NADPH Homo sapiens 11-cis-retinol + NAD+
-
r
11-cis-retinal + NADPH + H+
-
Homo sapiens 11-cis-retinol + NADP+
-
?
11-cis-retinal + NADPH + H+
-
Homo sapiens 11-cis-retinol + NADP+
-
r
9-cis-retinol + NADP+
-
Homo sapiens 9-cis-retinal + NADPH + H+
-
?
all-trans retinal + NADH + H+ NADH much less efficient than NADPH Homo sapiens all-tans-retinol + NAD+
-
r
all-trans retinal + NADPH + H+
-
Homo sapiens all-tans-retinol + NADP+
-
r
all-trans-retinal + NADPH + H+
-
Homo sapiens all-trans-retinol + NADP+
-
?
n-nonanal + NADPH + H+ might play a role in detoxification of lipid peroxidation products Homo sapiens n-nonanol + NADP+
-
r

Synonyms

Synonyms Comment Organism
RDH12
-
Homo sapiens
retinol dehydrogenase 12
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+ much less efficient than NADP+ Homo sapiens
NADH NADH much less efficient than NADPH Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens