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Literature summary for 1.1.1.30 extracted from

  • Kanazawa, H.; Hoque, M.M.; Tsunoda, M.; Suzuki, K.; Yamamoto, T.; Kawai, G.; Kondo, J.; Takenaka, A.
    Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase (2016), Acta Crystallogr. Sect. F, 72, 507-515.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with NAD+, malonate, or methylmalonate, hanging drop vapor diffusion method, using 30-34% (w/v) PEG 4000 Alcaligenes faecalis

Inhibitors

Inhibitors Comment Organism Structure
malonate
-
 Alcaligenes faecalis
methylmalonate
-
 Alcaligenes faecalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Alcaligenes faecalis
-
 acetoacetate + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Alcaligenes faecalis D0VWQ0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Alcaligenes faecalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
 Alcaligenes faecalis acetoacetate + NADH + H+
-
 r

Subunits

Subunits Comment Organism
homotetramer x-ray crystallography Alcaligenes faecalis

Synonyms

Synonyms Comment Organism
D-3-hydroxybutyrate dehydrogenase
-
 Alcaligenes faecalis
HBDH
-
 Alcaligenes faecalis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Alcaligenes faecalis