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Literature summary for 1.1.1.30 extracted from

  • Mountassif, D.; Kabine, M.; Karima Mounchi, K.M.; Mounaji, K.; Latruffe, N.; El Kebbaj, M.S.
    Biochemical and histological alterations of cellular metabolism from jerboa (Jaculus orientalis) by 2,4-dichlorophenoxyacetic acid: Effects on D-3-hydroxybutyrate dehydrogenase (2008), Pestic. Biochem. Physiol., 90, 87-96.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2,4-Dichlorophenoxyacetic acid inhibits the enzyme, in vivo treatment of the animals with 2,4-dichlorophenoxyacetic acid leads to strong decrease of triglycerides level and HDL cholesterol and an increase in GOT level and LDL cholesterol, and necrosis of seminiferous tubules cells in testis, hyperplasia of hepatocytes in liver and presence of multinucleated giant cells in brain, overview Jaculus orientalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
NAD+ pH 8.0, 25°C Jaculus orientalis
1.6
-
(R)-3-hydroxybutanoate pH 8.0, 25°C Jaculus orientalis

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Jaculus orientalis 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Jaculus orientalis
-
acetoacetate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Jaculus orientalis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Jaculus orientalis
-
liver
-
Jaculus orientalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
Jaculus orientalis acetoacetate + NADH
-
r

Synonyms

Synonyms Comment Organism
BDH
-
Jaculus orientalis
D-3-hydroxybutyrate dehydrogenase
-
Jaculus orientalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Jaculus orientalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Jaculus orientalis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Jaculus orientalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.38
-
2,4-Dichlorophenoxyacetic acid pH 8.0, 25°C, versus NAD+ Jaculus orientalis
5.74
-
2,4-Dichlorophenoxyacetic acid pH 8.0, 25°C, versus (R)-3-hydroxybutanoate Jaculus orientalis