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Literature summary for 1.1.1.3 extracted from

  • Bueno, P.S.A.; Rodrigues, F.A.V.; Santos, J.L.; Canduri, F.; Biavatti, D.C.; Pimentel, A.L.; Bagatin, M.C.; Kioshima, E.S.; de Freitas Gauze, G.; Seixas, F.A.V.
    New inhibitors of homoserine dehydrogenase from Paracoccidioides brasiliensis presenting antifungal activity (2019), J. Mol. Model., 25, 325 .
    View publication on PubMed
Search for more literature for 1.1.1.3

Application

Application Comment Organism
drug development HSD is an interesting metabolic target in the search for drugs with selective antifungal action and low toxicity to the host Paracoccidioides brasiliensis

Inhibitors

Inhibitors Comment Organism Structure
additional information PbHSD inhibitor screening using the Zinc library, molecular dynamics simulations of PbHSD and ligand docking, electrostatic contacts between protein residues and the respective ligand atoms, overview. The selected ligands remain bound to the protein by a common mechanism throughout the simulation. Cytotoxicity evaluation in HeLa and Vero cells Paracoccidioides brasiliensis
Zinc15967722 MIC/MCF is 0.032 mg/ml Paracoccidioides brasiliensis
Zinc20611644 MIC/MCF is 0.128 mg/ml Paracoccidioides brasiliensis
Zinc2123137 MIC/MCF is 0.008 mg/ml Paracoccidioides brasiliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-homoserine + NAD+ Paracoccidioides brasiliensis
-
 L-aspartate 4-semialdehyde + NADH + H+
-
 r
L-homoserine + NAD+ Paracoccidioides brasiliensis PB18
-
 L-aspartate 4-semialdehyde + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Paracoccidioides brasiliensis C1G1C3
-
-
Paracoccidioides brasiliensis PB18 C1G1C3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homoserine + NAD+
-
 Paracoccidioides brasiliensis L-aspartate 4-semialdehyde + NADH + H+
-
 r
L-homoserine + NAD+
-
 Paracoccidioides brasiliensis PB18 L-aspartate 4-semialdehyde + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
PbHSD
-
 Paracoccidioides brasiliensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Paracoccidioides brasiliensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Paracoccidioides brasiliensis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Paracoccidioides brasiliensis
NADH
-
 Paracoccidioides brasiliensis

General Information

General Information Comment Organism
physiological function the homoserine dehydrogenase enzyme is essentially required for the biosynthesis of methionine, threonine, and isoleucine in fungi Paracoccidioides brasiliensis