Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-carboxypropylidenemalate | - |
Saccharomyces cerevisiae | |
Cl- | - |
Saccharomyces cerevisiae | |
NADH | product inhibitor | Saccharomyces cerevisiae | |
potassium acetate | - |
Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | best activator, 200 mM activates by 100%, increases the affinity of enzyme for NAD+ at high pH | Saccharomyces cerevisiae | |
additional information | 200 mM Cs+, Li+, and Na+ do not activate | Saccharomyces cerevisiae | |
NH4+ | 200 mM activates by 80.9% | Saccharomyces cerevisiae | |
Rb+ | 200 mM activates by 29.3% | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
homoisocitrate + NAD+ | Saccharomyces cerevisiae | - |
? + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
homoisocitrate + NAD+ | - |
Saccharomyces cerevisiae | ? + NADH | - |
? | |
isocitrate + NAD+ | slow substrate | Saccharomyces cerevisiae | 2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HICDH | - |
Saccharomyces cerevisiae |
homoisocitrate dehydrogenase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.7 | - |
NADH | - |
Saccharomyces cerevisiae | |
90 | - |
Cl- | - |
Saccharomyces cerevisiae | |
500 | - |
potassium acetate | - |
Saccharomyces cerevisiae |