Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial progenitor cell | - |
Mus musculus | - |
mesenchymal stem cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
GSNOR | - |
Mus musculus |
S-nitrosoglutathione reductase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mesenchymal stem cells deficient in GSNOR exhibit markedly diminished capacity for vasculogenesis in an in vitro Matrigel tubeforming assay and in vivo relative to wild-type cells. This decrease is associated with downregulation of the PDGF receptor alpha in GSNOR-/- mesenchymal stem cells, a receptor essential for VEGF-A action in the cells. GSNOR-/- mesenchymal stem cells have a deficient capacity for endothelial differentiation due to downregulation of PDGFRalpha related to NO/GSNOR imbalance, overview | Mus musculus |
physiological function | S-nitrosoglutathione reductase is a denitrosylase that regulates S-nitrosylation | Mus musculus |