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Literature summary for 1.1.1.284 extracted from

  • Kidd, S.P.; Jiang, D.; Jennings, M.P.; McEwan, A.G.
    Glutathione-dependent alcohol dehydrogenase AdhC is required for defense against nitrosative stress in Haemophilus influenzae (2007), Infect. Immun., 75, 4506-4513.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene adhC, encoded in the adhC-estD operon, expression of the adhC-estD operon is regulated by NmlRHI in strain Rd KW20, the Neisseria MerR-like regulator, overview. The NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, in silico promoter analysis, overview Haemophilus influenzae

Protein Variants

Protein Variants Comment Organism
additional information chromosomal inactivation of either adhC or nmlRHI resulted in sensitivity to S-nitrosoglutathione and decreased S-nitrosoglutathione reductase activity, the NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, overview Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Haemophilus influenzae genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview ?
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?
additional information Haemophilus influenzae KW20 genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview ?
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?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae A5HES9 strain Rd KW20, gene adhC
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Haemophilus influenzae KW20 A5HES9 strain Rd KW20, gene adhC
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview Haemophilus influenzae ?
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?
additional information AdhC has NADH-dependent S-nitrosoglutathione reductase activity Haemophilus influenzae ?
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?
additional information genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview Haemophilus influenzae KW20 ?
-
?
additional information AdhC has NADH-dependent S-nitrosoglutathione reductase activity Haemophilus influenzae KW20 ?
-
?

Synonyms

Synonyms Comment Organism
AdhC
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Haemophilus influenzae
class III alcohol dehydrogenase
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Haemophilus influenzae
glutathione-dependent alcohol dehydrogenase
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Haemophilus influenzae
GSNO reductase
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Haemophilus influenzae
NADH-GSNO oxidoreductase
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Haemophilus influenzae
S-nitrosoglutathione reductase
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Haemophilus influenzae

Cofactor

Cofactor Comment Organism Structure
NADH dependent on Haemophilus influenzae