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Literature summary for 1.1.1.270 extracted from

  • Rizner, T.L.; Lin, H.K.; Peehl, D.M.; Steckelbroeck, S.; Bauman, D.R.; Penning, T.M.
    Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells (2003), Endocrinology, 144, 2922-2932.
    View publication on PubMed
Search for more literature for 1.1.1.270

Inhibitors

Inhibitors Comment Organism Structure
NADPH the NAD+:NADPH ratio in cell will determinewhether AKR1C2 makes 5alpha-dihydrotestosterone Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NADPH + H+ Homo sapiens in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-hydroxysteroid dehydrogenase present. AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells 5alpha-androstan-3alpha,17beta-diol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells Homo sapiens
-
prostate in primary cultures of epithelial cells, high levels of AKR1C2 transcripts are detected in prostate cancer, but not in cell from normal prostate. In prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor Homo sapiens
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prostate cancer cell in primary cultures of epithelial cells, high levels of AKR1C2 transcripts are detected in prostate cancer, but not in cell from normal prostate Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-androstanediol + NAD+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADH
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 ?
5alpha-dihydrotestosterone + NADPH + H+
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 Homo sapiens 5alpha-androstan-3alpha,17beta-diol + NADP+
-
 ?
5alpha-dihydrotestosterone + NADPH + H+ in prostate cells AKR1C2 acts as a 3-ketosteroid reductase to eliminate 5alpha-dihydrotestosterone and prevents activation of androgen receptor. AKR1C2 does not act as an oxidase due to either potent product inhibition by NADPH or because it cannot surmount the oxidative 17beta-hydroxysteroid dehydrogenase present. AKR1C2 is not a source of 5alpha-dihydrotestosterone in PC-3 cells Homo sapiens 5alpha-androstan-3alpha,17beta-diol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
AKR1C2
-
 Homo sapiens
aldo-keto reductase 1C2
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 Homo sapiens
type 3 3alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens