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Literature summary for 1.1.1.270 extracted from

  • De Launoit, Y.; Zhao, H.F.; Belanger, A.; Labrie, F.; Simard, J.
    Expression of liver-specific member of the 3beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity (1992), J. Biol. Chem., 267, 4513-4517.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
isoform type III of 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase with almost exclusive 3-ketosteroid reductase activity, cDNA expression Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
trilostane IC50: 0.00023 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00012
-
NADPH substrate: 5alpha-dihydrotestosterone, DHT Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus catalyzes the conversion of 3-keto-saturated steroids such as 5alpha-dihydrotestosterone, DHT, and 5alpha-androstane-3,17-dione, A-dione, into less active steroids ?
-
?
additional information Rattus norvegicus step of biosynthesis of hormonal steroids ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male rat
-
Rattus norvegicus
-
isoform type III of 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase with almost exclusive 3-ketosteroid reductase activity
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxy-5alpha-androstan-3-one + NADPH 5alpha-dihydrotestosterone Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH 5alpha-dihydrotestosterone Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ corresponding 3beta-hydroxysteroid ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH DHT Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH DHT Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ corresponding 3beta-hydroxysteroid ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH dihydrotestosterone Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ androstanediol ir
17beta-hydroxy-5alpha-androstan-3-one + NADPH dihydrotestosterone Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+ corresponding 3beta-hydroxysteroid ir
3-keto-5alpha-androstane steroids + NADPH
-
Rattus norvegicus 3beta-hydroxy-5alpha-androstane steroids + NADP+
-
ir
5alpha-androstane-3,17-dione + NADPH A-dione Rattus norvegicus epi-androsterone + NADP+
-
ir
additional information substrate specificity Rattus norvegicus ?
-
?
additional information catalyzes the conversion of 3-keto-saturated steroids such as 5alpha-dihydrotestosterone, DHT, and 5alpha-androstane-3,17-dione, A-dione, into less active steroids Rattus norvegicus ?
-
?
additional information step of biosynthesis of hormonal steroids Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH NADPH preferred cofactor for 3-ketoreductase activity expressed type III isoform Rattus norvegicus
NADPH specific for NADPH, NADH is essentially inactive, less than 10% Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00023
-
IC50: 0.00023 mM Rattus norvegicus trilostane