Application | Comment | Organism |
---|---|---|
medicine | structural characterization of the enzyme and active-site differences from the human lactate dehydrogenase may be useful for structural-based design of new treatments for toxoplasmic infections | Toxoplasma gondii |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Toxoplasma gondii |
Crystallization (Comment) | Organism |
---|---|
in apo-form and in ternary complexes containing NAD+ or NAD+-analogue 3-acetylpyridine adenine dinucleotide and sulfate or the inhibitor oxalate | Toxoplasma gondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + NADH + H+ | Toxoplasma gondii | terminal enzyme in aerobic glycolysis necessary for NAD+ regeneration | (S)-lactate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | P90613 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Toxoplasma gondii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + NADH + H+ | - |
Toxoplasma gondii | (S)-lactate + NAD+ | - |
? | |
pyruvate + NADH + H+ | terminal enzyme in aerobic glycolysis necessary for NAD+ regeneration | Toxoplasma gondii | (S)-lactate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LDH1 | - |
Toxoplasma gondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Toxoplasma gondii |