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Literature summary for 1.1.1.267 extracted from

  • Rad, M.; Abdossi, V.; Moradi, P.; Rakhshandehroo, F.; Mehrafarin, A.
    Expression analysis of gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) and cardenolide and digitoxin production in digitalis purpurea L. using polyamines and methyl jasmonate as elicitors (2020), J. Agric. Sci. Technol., 22, 1551-1561 .
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
gene DXR, semi-quantitative RT-PCR enzyme expression analysis Digitalis purpurea

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Digitalis purpurea 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Digitalis purpurea
-
 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Digitalis purpurea
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
callus
-
 Digitalis purpurea
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 Digitalis purpurea 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
1-deoxy-D-xylulose 5-phosphate reductoisomerase
-
 Digitalis purpurea
DXR
-
 Digitalis purpurea

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Digitalis purpurea
NADPH
-
 Digitalis purpurea

Expression

Organism Comment Expression
Digitalis purpurea elicitors have significant effects on the expression level of DXR and contents of cardenolide and digitoxin additional information
Digitalis purpurea the enzyme is induced by methyljasmonate, synergistically increased by polyamines spermidine, spermine, and putrescine. 100 mg/l spermidine + 0.05 mM methyljasmonate lead to 4.1 and 2.4folds increase of cardenolide and digitoxin compared to the control, respectively. The lowest induction levels of cardenolide and digitoxin are obtained by 0.2 mM methyljasmonate without polyamine up

General Information

General Information Comment Organism
physiological function 1-deoxy-xylulose-5-phosphate isomerase-reductase gene (DXR), catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP), which is the key element for MEP-pathway that supports the main C5 units for the formation of mono and diterpenes. Plastidial MEP pathway is considered as the main important source of precursors for essential plastid isoprenoids Digitalis purpurea