Literature summary for 1.1.1.267 extracted from

Munos, J.; Pu, X.; Liu, H.
Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (2008), Bioorg. Med. Chem. Lett., 18, 3090-3094.

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Inhibitors

Inhibitors	Comment	Organism	Structure
phosphate mono-((2S,3S)-3-fluoromethyl-2,4-dihydroxy-3-methyl-butyl) ester	is a weak competitive inhibitor of DXR, most likely due to the steric hindrance caused by the substitution of a fluoromethylgroup for a hydroxyl group. Is not an irreversible inactivator (suicide inhibitor) for DXR, fails to act as a mechanism-based inactivator if the retroaldol/aldol mechanism is operative	synthetic construct

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mono-((2S,3S)-3-fluoromethyl-2,4-dihydroxy-3-methyl-butyl) ester is not a substrate for DXR	synthetic construct	?	-	?

Synonyms

Synonyms	Comment	Organism
DXP reductoisomerase	-	synthetic construct
DXR	-	synthetic construct

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Release 2023.1 (January 2023)