BRENDA - Enzyme Database show
show all sequences of 1.1.1.267

A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase

Merckle, L.; de Andres-Gomez, A.; Dick, B.; Cox, R.J.; Godfrey, C.R.; Chembiochem 6, 1866-1874 (2005)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
fosmidomycin
acts by binding strongly to DXR as a slow tight-binding inhibitor, inhibitor-enzyme interaction and structure analysis for design of inhibitors, possibly mimics a transition state in the reaction coordinate of the substrate, the initial rapid equilibrium is subject to negative cooperativity, overview
Escherichia coli
fosmidomycin analogues
synthesis, stereochemistry, and analysis of inhibitory potency of several fosmidomycin analogues, overview
Escherichia coli
FR 900098
N-acetyl analogue of fosmidomycin
Escherichia coli
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mn2+
bound to the enzymes' active site
Escherichia coli
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
Escherichia coli
key enzyme in the bacterial nonmevalonate pathway to terpenoids, DXR introduces the key branching structure required for the eventual production of isopentenyl diphosphate
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
P45568
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
673073
Escherichia coli
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
-
?
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
key enzyme in the bacterial nonmevalonate pathway to terpenoids, DXR introduces the key branching structure required for the eventual production of isopentenyl diphosphate
673073
Escherichia coli
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Escherichia coli
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Escherichia coli
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Escherichia coli
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics
Escherichia coli
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
fosmidomycin
acts by binding strongly to DXR as a slow tight-binding inhibitor, inhibitor-enzyme interaction and structure analysis for design of inhibitors, possibly mimics a transition state in the reaction coordinate of the substrate, the initial rapid equilibrium is subject to negative cooperativity, overview
Escherichia coli
fosmidomycin analogues
synthesis, stereochemistry, and analysis of inhibitory potency of several fosmidomycin analogues, overview
Escherichia coli
FR 900098
N-acetyl analogue of fosmidomycin
Escherichia coli
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics
Escherichia coli
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mn2+
bound to the enzymes' active site
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
Escherichia coli
key enzyme in the bacterial nonmevalonate pathway to terpenoids, DXR introduces the key branching structure required for the eventual production of isopentenyl diphosphate
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
673073
Escherichia coli
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
-
?
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
key enzyme in the bacterial nonmevalonate pathway to terpenoids, DXR introduces the key branching structure required for the eventual production of isopentenyl diphosphate
673073
Escherichia coli
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Escherichia coli
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Escherichia coli
Other publictions for EC 1.1.1.267
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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2
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2
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741430
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740825
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Molecular cloning, characteriz ...
Aquilaria sinensis
J. Genet.
94
239-249
2015
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1
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1
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736693
Mendoza-Poudereux
Deoxyxylulose 5-phosphate redu ...
Arabidopsis thaliana
J. Plant Physiol.
171
1564-1570
2014
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4
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1
1
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740062
Kholodar
Alteration of the flexible loo ...
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53
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4
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1
3
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6
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3
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1
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4
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3
3
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2
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3
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3
3
740160
Zingle
Catechol-rhodanine derivatives ...
Escherichia coli, Escherichia coli UPEC
Bioorg. Med. Chem.
22
3713-3719
2014
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2
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741292
Haymond
Kinetic characterization and a ...
Yersinia pestis
PLoS ONE
9
e106243
2014
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1
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2
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1
1
723812
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Escherichia coli, Plasmodium falciparum
ACS Med. Chem. Lett.
4
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2013
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1
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15
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15
14
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2
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2
2
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724374
Kholodar
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52
2302-2308
2013
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1
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3
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2
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1
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1
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1
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2
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3
3
724543
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Expression, characterization a ...
Toxoplasma gondii
Bioorg. Med. Chem. Lett.
23
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2013
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1
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12
1
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3
1
1
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5
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1
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1
1
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11
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11
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1
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1
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724558
Bodill
Exploring DOXP-reductoisomeras ...
Escherichia coli, Plasmodium falciparum
Bioorg. Med. Chem.
21
4332-4341
2013
-
1
2
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29
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2
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29
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2
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740430
Li
Mechanistic insights into 1-de ...
Escherichia coli, Escherichia coli O157
FEBS J.
280
5896-5905
2013
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740943
San Jose
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MedChemComm
4
1099-1104
2013
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2
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720429
Yang
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39
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2012
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1
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2
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724346
Liu
Pre-steady-state kinetic analy ...
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51
5307-5319
2012
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1
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4
725564
Humnabadkar
A high-throughput screening as ...
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J. Biomol. Screen.
16
303-312
2011
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725663
Andaloussi
Design, synthesis, and X-ray c ...
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J. Med. Chem.
54
4964-4976
2011
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1
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21
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1
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6
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14
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21
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705372
Sitthithaworn
Cloning and expression of 1-de ...
Croton stellatopilosus
J. Plant Physiol.
167
292-300
2010
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2
1
1
2
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710752
Umeda
Crystallization and preliminar ...
Plasmodium falciparum
Acta Crystallogr. Sect. F
66
330-332
2010
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1
1
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1
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4
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1
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711702
Xing
Disruption of the 1-deoxy-D-xy ...
Arabidopsis thaliana
Cell Res.
20
688-700
2010
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1
1
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712892
Takenoya
Crystal structure of 1-deoxy-d ...
Thermotoga maritima
J. Struct. Biol.
170
532-539
2010
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1
1
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4
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4
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2
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1
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Goble
The malarial drug target Plasm ...
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Yan
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Molecular characterization and ...
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Munos
A secondary kinetic isotope ef ...
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Unravelling the regulatory mec ...
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701348
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Regulation of resin acid synth ...
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The 1-deoxy-D: -xylulose 5-pho ...
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Coordination chemistry based a ...
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Jawaid
Kinetic characterization and p ...
Francisella tularensis
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1
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2
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1
1
1
2
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2
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1
1
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1
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2
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Wungsintaweekul
Transcription profiles analysi ...
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3
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Wu
Cloning and characterization o ...
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1
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1
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1
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1
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Hasunuma
Overexpression of 1-deoxy-D-xy ...
Synechocystis sp.
J. Biosci. Bioeng.
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2008
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1
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1
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1
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688641
Yao
Molecular cloning, expression ...
Camptotheca acuminata
J. Plant Physiol.
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203-213
2008
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1
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1
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1
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1
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1
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1
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3
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1
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Seetang-Nun
Molecular cloning and characte ...
Hevea brasiliensis
J. Plant Physiol.
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991-1002
2008
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5
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1
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2
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2
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7
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2
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688915
Zhang
Identification and characteriz ...
Glycine max
Mol. Biol. Rep.
36
879-887
2008
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1
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1
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1
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1
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1
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1
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1
-
1
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1
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1
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1
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691382
Sando
Cloning and characterization o ...
Arabidopsis thaliana, Escherichia coli, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
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3
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3
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7
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1
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3
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3
-
1
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3
3
-
3
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1
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1
-
-
3
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1
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696620
Munos
Synthesis and analysis of a fl ...
synthetic construct
Bioorg. Med. Chem. Lett.
18
3090-3094
2008
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1
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1
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1
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1
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-
1
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-
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697249
Giessmann
Towards new antimalarial drugs ...
Escherichia coli, Plasmodium falciparum
Chem. Biodivers.
5
643-656
2008
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2
2
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30
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4
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2
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2
2
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-
-
-
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2
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30
-
2
2
2
-
-
-
30
30
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-
-
-
-
-
-
-
-
2
-
-
-
2
2
-
-
-
-
-
-
-
-
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697335
Perruchon
Studies addressing the importa ...
Escherichia coli
ChemMedChem
3
1232-1241
2008
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-
-
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11
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2
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1
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-
-
-
-
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1
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-
-
-
-
-
-
1
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10
-
-
-
1
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-
-
10
11
-
-
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2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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697870
Lauw
Biosynthesis of isoprenoids: s ...
Arabidopsis thaliana, Bacillus subtilis, Escherichia coli, Mycobacterium tuberculosis
FEBS J.
275
4060-4073
2008
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1
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7
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13
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6
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1
6
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-
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-
-
-
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-
-
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-
-
13
-
-
-
-
-
-
-
-
-
-
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-
-
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700838
Yoonram
cDNA, from Hevea brasiliensis ...
Hevea brasiliensis
Plant Sci.
175
694-700
2008
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1
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
-
1
1
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-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
1
-
-
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-
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-
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684210
Yajima
Structure of 1-deoxy-D-xylulos ...
Escherichia coli
Acta Crystallogr. Sect. F
F63
466-470
2007
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1
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1
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2
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-
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-
1
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1
1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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684379
Tahar
Molecular epidemiology of mala ...
Plasmodium falciparum
Am. J. Trop. Med. Hyg.
77
214-220
2007
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1
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4
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5
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2
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1
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-
-
-
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2
4
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-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
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-
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-
-
-
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-
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684434
Wong
The chemical mechanism of D-1- ...
Escherichia coli
Angew. Chem. Int. Ed. Engl.
46
4926-4929
2007
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-
-
-
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-
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3
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1
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1
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3
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-
-
-
-
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-
-
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-
-
-
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-
3
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-
-
3
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-
-
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-
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684769
Ortmann
Novel deoxyxylulosephosphate-r ...
Escherichia coli
Arch. Pharm.
340
483-490
2007
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1
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6
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1
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1
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Henriksson
Structures of Mycobacterium tu ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Biol. Chem.
282
19905-19916
2007
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1
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1
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1
1
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1
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1
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689434
Kaiser
Anti-malarial drug targets: sc ...
Escherichia coli
Phytomedicine
14
242-249
2007
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6
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5
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6
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-
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689559
Phillips
Functional identification and ...
Picea abies
Plant Mol. Biol.
65
243-257
2007
2
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4
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1
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690214
Liao
A new 1-Deoxy-D-xylulose 5-pho ...
Rauvolfia verticillata
Z. Naturforsch. C
62
296-304
2007
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1
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1
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1
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1
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1
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5
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1
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1
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671075
Henriksson
The 1.9 A resolution structure ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
D62
807-813
2006
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1
1
1
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1
1
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1
1
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2
1
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1
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1
1
1
1
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1
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2
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1
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2
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1
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4
1
1
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2
1
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672396
Fernandes
Kinetic characterization of Sy ...
Synechocystis sp.
Biochim. Biophys. Acta
1764
223-229
2006
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1
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12
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1
1
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1
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1
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2
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1
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1
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1
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1
1
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12
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Woo
Evaluation of fosmidomycin ana ...
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Rohdich
Isoprenoid biosynthesis in pla ...
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2
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1
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675038
Singh
Comparative protein modeling o ...
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2
1
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676736
Kim
Identification of class 2 1-de ...
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Mac Sweeney
The crystal structure of E. co ...
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Fernandes
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1
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4
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1
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672040
Fox
Mechanistic studies with 2-C-m ...
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Biochemistry
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1
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673073
Merckle
A fragment-based approach to u ...
Escherichia coli
Chembiochem
6
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2005
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1
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1
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2
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Dhiman
1-Deoxy-D-xylulose 5-phosphate ...
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Fox
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Engprasert
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Argyrou
Kinetic and chemical mechanism ...
Mycobacterium tuberculosis
Biochemistry
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2004
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4
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Ricagno
Crystal structure of 1-deoxy-D ...
Zymomonas mobilis
Biochim. Biophys. Acta
1698
37-44
2004
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Phaosiri
Substrate analogs for the inve ...
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Yajima
Crystallographic structures of ...
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Wong
Study of 1-deoxy-D-xylulose-5- ...
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Org. Lett.
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3625-3628
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Hans
Cloning, characterization, and ...
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614-624
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Yin
Characterization of native and ...
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Biochim. Biophys. Acta
1652
75-81
2003
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Yajima
Crystal structure of 1-deoxy-D ...
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Reuter
Crystal structure of 1-deoxy-D ...
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J. Biol. Chem.
277
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Hoeffler
Isoprenoid biosynthesis via th ...
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Carretero-Paulet
Expression and molecular analy ...
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Mahmoud
Metabolic engineering of essen ...
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286421
Radykewicz
Biosynthesis of terpenoids: 1- ...
Escherichia coli
FEBS Lett.
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Grolle
Isolation of the dxr gene of Z ...
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FEMS Microbiol. Lett.
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1
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Altincicek
Tools for discovery of inhibit ...
Pseudomonas aeruginosa
FEMS Microbiol. Lett.
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1
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286428
Kuzuyama
Characterization of 1-deoxy-D- ...
Escherichia coli
J. Biol. Chem.
275
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1
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5
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1
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286429
Wiesner
Plasmodium falciparum: Detecti ...
Plasmodium falciparum
Exp. Parasitol.
96
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2000
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1
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1
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286426
Lange
Isoprenoid biosynthesis via a ...
Mentha x piperita
Arch. Biochem. Biophys.
365
170-174
1999
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286427
Takahashi
A 1-deoxy-D-xylulose 5-phospha ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
95
9879-9884
1998
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