KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
codeinone | isoenzymes from capsule tissue | Papaver somniferum | |
0.023 | - |
codeinone | enzyme from cell culture | Papaver somniferum | |
0.026 | - |
Hydrocodone | isoenzymes from capsule tissue | Papaver somniferum | |
0.027 | - |
Hydrocodone | enzyme from cell culture | Papaver somniferum | |
0.027 | - |
Hydrocodone | morphine, enzyme from cell culture | Papaver somniferum | |
0.029 | - |
NADP+ | enzyme from cell culture | Papaver somniferum | |
0.042 | - |
Hydromorphone | isoenzymes from capsule tissue | Papaver somniferum | |
0.047 | - |
NADP+ | isoenzymes from capsule tissue | Papaver somniferum | |
0.05 | - |
Hydromorphone | enzyme from cell culture | Papaver somniferum | |
0.063 | - |
morphine | isoenzymes from capsule tissue | Papaver somniferum | |
0.076 | - |
codeine | enzyme from cell culture | Papaver somniferum | |
0.081 | - |
NADPH | isoenzymes from capsule tissue | Papaver somniferum | |
0.168 | - |
NADPH | enzyme from cell culture | Papaver somniferum | |
0.178 | - |
codeine | isoenzymes from capsule tissue | Papaver somniferum | |
0.422 | - |
Dihydrocodeine | isoenzymes from capsule tissue | Papaver somniferum | |
0.424 | - |
Dihydrocodeine | enzyme from cell culture | Papaver somniferum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Papaver somniferum | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
gel filtration | Papaver somniferum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Codeinone + NADPH | Papaver somniferum | biosynthesis of codeine | Codeine + NADP+ | - |
? | |
Morphinone + NADPH | Papaver somniferum | biosynthesis of morphine | Morphine + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
2 isoenzymes from capsule tissue, enzyme from cell culture | Papaver somniferum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Papaver somniferum | - |
leaf | - |
Papaver somniferum | - |
plant capsule | - |
Papaver somniferum | - |
root | - |
Papaver somniferum | - |
shoot | - |
Papaver somniferum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Papaver somniferum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Codeinone + NADPH | r | Papaver somniferum | Codeine + NADP+ | (-)codeine | ? | |
Codeinone + NADPH | (-)codeinone | Papaver somniferum | Codeine + NADP+ | (-)codeine | ? | |
Codeinone + NADPH | no reaction with NADH and NAD+ | Papaver somniferum | Codeine + NADP+ | (-)codeine | ? | |
Codeinone + NADPH | biosynthesis of codeine | Papaver somniferum | Codeine + NADP+ | - |
? | |
Dihydrocodeine + NADP+ | - |
Papaver somniferum | ? | - |
? | |
Hydrocodone + NADPH | - |
Papaver somniferum | ? | - |
? | |
Hydromorphone + NADPH | - |
Papaver somniferum | ? | - |
? | |
Morphinone + NADPH | - |
Papaver somniferum | Morphine + NADP+ | - |
? | |
Morphinone + NADPH | biosynthesis of morphine | Papaver somniferum | Morphine + NADP+ | - |
? | |
Naloxone + NADPH | - |
Papaver somniferum | ? | - |
? | |
Naltrexone + NADPH | - |
Papaver somniferum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 34000-35000, SDS-PAGE | Papaver somniferum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
reduction of codeinone | Papaver somniferum |
46 | - |
oxidation of codeine | Papaver somniferum |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
29 | 47 | 50% of maximal activity at 29°C and 47°C, reduction of codeinone | Papaver somniferum |
34 | 53 | 50% of maximal activity at 34°C and 53°C, oxidation of codeine | Papaver somniferum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
reduction of codeinone | Papaver somniferum |
9.1 | - |
oxidation of codeine | Papaver somniferum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 7.6 | 50% of maximal activity at pH 6.2 and pH 7.6, reduction of codeinone | Papaver somniferum |
8.2 | 9.8 | 50% of maximal activity at pH 8.2 and pH 9.8, oxidation of codeine | Papaver somniferum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Papaver somniferum | |
NADPH | - |
Papaver somniferum |