Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.247 extracted from

  • Lenz, R.; Zenk, M.H.
    Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants (1995), Eur. J. Biochem., 233, 132-139.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
codeinone isoenzymes from capsule tissue Papaver somniferum
0.023
-
codeinone enzyme from cell culture Papaver somniferum
0.026
-
Hydrocodone isoenzymes from capsule tissue Papaver somniferum
0.027
-
Hydrocodone enzyme from cell culture Papaver somniferum
0.027
-
Hydrocodone morphine, enzyme from cell culture Papaver somniferum
0.029
-
NADP+ enzyme from cell culture Papaver somniferum
0.042
-
Hydromorphone isoenzymes from capsule tissue Papaver somniferum
0.047
-
NADP+ isoenzymes from capsule tissue Papaver somniferum
0.05
-
Hydromorphone enzyme from cell culture Papaver somniferum
0.063
-
morphine isoenzymes from capsule tissue Papaver somniferum
0.076
-
codeine enzyme from cell culture Papaver somniferum
0.081
-
NADPH isoenzymes from capsule tissue Papaver somniferum
0.168
-
NADPH enzyme from cell culture Papaver somniferum
0.178
-
codeine isoenzymes from capsule tissue Papaver somniferum
0.422
-
Dihydrocodeine isoenzymes from capsule tissue Papaver somniferum
0.424
-
Dihydrocodeine enzyme from cell culture Papaver somniferum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Papaver somniferum 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
gel filtration Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Codeinone + NADPH Papaver somniferum biosynthesis of codeine Codeine + NADP+
-
?
Morphinone + NADPH Papaver somniferum biosynthesis of morphine Morphine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 isoenzymes from capsule tissue, enzyme from cell culture Papaver somniferum

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Papaver somniferum
-
leaf
-
Papaver somniferum
-
plant capsule
-
Papaver somniferum
-
root
-
Papaver somniferum
-
shoot
-
Papaver somniferum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Papaver somniferum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Codeinone + NADPH r Papaver somniferum Codeine + NADP+ (-)codeine ?
Codeinone + NADPH (-)codeinone Papaver somniferum Codeine + NADP+ (-)codeine ?
Codeinone + NADPH no reaction with NADH and NAD+ Papaver somniferum Codeine + NADP+ (-)codeine ?
Codeinone + NADPH biosynthesis of codeine Papaver somniferum Codeine + NADP+
-
?
Dihydrocodeine + NADP+
-
Papaver somniferum ?
-
?
Hydrocodone + NADPH
-
Papaver somniferum ?
-
?
Hydromorphone + NADPH
-
Papaver somniferum ?
-
?
Morphinone + NADPH
-
Papaver somniferum Morphine + NADP+
-
?
Morphinone + NADPH biosynthesis of morphine Papaver somniferum Morphine + NADP+
-
?
Naloxone + NADPH
-
Papaver somniferum ?
-
?
Naltrexone + NADPH
-
Papaver somniferum ?
-
?

Subunits

Subunits Comment Organism
monomer 34000-35000, SDS-PAGE Papaver somniferum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
reduction of codeinone Papaver somniferum
46
-
oxidation of codeine Papaver somniferum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
29 47 50% of maximal activity at 29°C and 47°C, reduction of codeinone Papaver somniferum
34 53 50% of maximal activity at 34°C and 53°C, oxidation of codeine Papaver somniferum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
reduction of codeinone Papaver somniferum
9.1
-
oxidation of codeine Papaver somniferum

pH Range

pH Minimum pH Maximum Comment Organism
6.2 7.6 50% of maximal activity at pH 6.2 and pH 7.6, reduction of codeinone Papaver somniferum
8.2 9.8 50% of maximal activity at pH 8.2 and pH 9.8, oxidation of codeine Papaver somniferum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Papaver somniferum
NADPH
-
Papaver somniferum