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Literature summary for 1.1.1.239 extracted from

  • Ohmura, M.; Hara, A.; Nakagawa, M.; Sawada, H.
    Demonstration of 3alpha(17beta)-hydroxysteroid dehydrogenase distinct from 3alpha-hydroxysteroid dehydrogenase in hamster liver (1990), Biochem. J., 266, 583-589.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
21-hydroxypregn-4-ene-3,20-dione 0.010 mM, 73% inhibition Mesocricetus auratus
5alpha-Androstan-3beta-ol-17-one 0.005 mM, 55% inhibition Mesocricetus auratus
5alpha-pregnan-3beta-ol-20-one 0.005 mM, 52% inhibition Mesocricetus auratus
5beta-androstan-3beta-ol-17-one 0.005 mM, 87% inhibition Mesocricetus auratus
5beta-Pregnan-3beta-ol-20-one 0.005 mM, 81% inhibition Mesocricetus auratus
dexamethasone 0.10 mM, 39% inhibition Mesocricetus auratus
Dienstrol 0.010 mM, 60% inhibition Mesocricetus auratus
Hexoestrol 0.010 mM, 62% inhibition Mesocricetus auratus
indomethacin 0.10 mM, 67% inhibition Mesocricetus auratus
Medroxyprogesterone acetate 0.010 mM, 22% inhibition Mesocricetus auratus
stilboestrol 0.010 mM, 61% inhibition Mesocricetus auratus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
lithocholic acid
-
Mesocricetus auratus
0.0022
-
testosterone
-
Mesocricetus auratus
0.003
-
glycolithocholic acid
-
Mesocricetus auratus
0.0031
-
5alpha-androstan-3alpha,17beta-diol
-
Mesocricetus auratus
0.0038
-
5beta-pregnan-3,20-dione
-
Mesocricetus auratus
0.0046
-
5beta-Pregnan-3alpha-ol-20-one
-
Mesocricetus auratus
0.0048
-
5beta-Androstan-3alpha,17beta-diol
-
Mesocricetus auratus
0.0049
-
5beta-androstan-17beta-ol-3-one
-
Mesocricetus auratus
0.0062
-
5beta-pregnan-3alpha,17beta-diol-20-one
-
Mesocricetus auratus
0.0066
-
5beta-androstan-3,17-dione
-
Mesocricetus auratus
0.0075
-
glycochenodeoxycholic acid
-
Mesocricetus auratus
0.02
-
NADH
-
Mesocricetus auratus
0.27
-
NAD+
-
Mesocricetus auratus

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2
-
-
Mesocricetus auratus

Storage Stability

Storage Stability Organism
4°C, 10 mM Tris/HCl buffer, pH 8.0, 5 mM 2-mercaptoethanol, 0.5 mM EDTA Mesocricetus auratus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androstan-3alpha,17beta-diol + NAD+
-
Mesocricetus auratus 5alpha-androstan-3alpha-ol-17-one + NADH
-
?
5alpha-pregnan-3,21alpha-diol-20-one + NAD+
-
Mesocricetus auratus 5alpha-pregnan-21-ol-3,20-dione + NADH
-
?
5beta-androstan-17beta-ol-3-one + NAD+
-
Mesocricetus auratus 5beta-androstan-3,17-dione + NADH
-
?
5beta-androstan-3alpha,17beta-diol + NAD+
-
Mesocricetus auratus 5beta-androstan-3alpha-ol-17-one + NADH
-
?
5beta-pregnan-3alpha,21-diol-20-one + NAD+
-
Mesocricetus auratus 5beta-pregnan-21-ol-3,20-dione + NADH
-
?
5beta-pregnan-3alpha-ol-20-one + NAD+
-
Mesocricetus auratus 5beta-pregnan-3,20-dione + NADH
-
?
glycochenodeoxycholic acid + NAD+
-
Mesocricetus auratus 7alpha-hydroxy-3-oxo-5-beta-cholanoyl glycine + NADH
-
?
glycolithocholic acid + NAD+
-
Mesocricetus auratus 3-oxo-5beta-cholanoyl glycine + NADH
-
?
lithocholic acid + NAD+
-
Mesocricetus auratus 5beta-cholan-3-one-24-oic acid + NADH
-
?
testosterone + NAD+
-
Mesocricetus auratus androst-4-ene-3,17-dione + NADH + H+
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
half-life 2.3 min Mesocricetus auratus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
glycochenodeoxycholic acid
-
Mesocricetus auratus
0.05
-
lithocholic acid
-
Mesocricetus auratus
0.158
-
5beta-pregnan-3,20-dione
-
Mesocricetus auratus
0.167
-
5beta-androstan-3,17-dione
-
Mesocricetus auratus
0.233
-
5beta-Pregnan-3alpha-ol-20-one
-
Mesocricetus auratus
0.25
-
glycolithocholic acid
-
Mesocricetus auratus
0.267
-
5alpha-Pregnan-3alpha,21-diol-20-one
-
Mesocricetus auratus
0.367
-
5beta-androstan-17beta-ol-3-one
-
Mesocricetus auratus
0.367
-
5beta-Pregnan-3alpha,21-diol-20-one
-
Mesocricetus auratus
0.417
-
testosterone
-
Mesocricetus auratus
0.45
-
5alpha-androstan-3alpha,17beta-diol
-
Mesocricetus auratus
0.85
-
5beta-Androstan-3alpha,17beta-diol
-
Mesocricetus auratus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.4
-
oxidation of 5beta-androstan-3alpha,17beta-diol Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NAD+ preferred Mesocricetus auratus
NADH preferred Mesocricetus auratus
NADP+ 15% of NAD+-activity Mesocricetus auratus
NADPH
-
Mesocricetus auratus