BRENDA - Enzyme Database show
show all sequences of 1.1.1.237

Enhanced rosmarinic acid biosynthesis in Solenostemon scutellarioides culture: a precursor-feeding strategy

Dewanjee, S.; Gangopadhyay, M.; Das, U.; Sahu, R.; Khanra, R.; Nat. Prod. Res. 28, 1691-1698 (2014)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
L-tyrosine
activates the enzyme
Plectranthus scutellarioides
Engineering
Amino acid exchange
Commentary
Organism
additional information
cultures fed with precursors, namely L-Phe, L-Tyr, and cucumber juice, at different concentrations show Phe an 1.5, 2.1, and 1.6fold increase in rosmarinic acid accumulation within 48-72 h, respectively. In this study, we focused on the function of individual precursor on key enzymes involved in RA biosynthesis. The phenylalanine ammonia lyase activity was significantly upregulated after Phe feeding, while tyrosine aminotransferase and hydroxyphenylpyruvate reductase activities are improved with Tyr treatment. Rosmarinic acid synthase activity is significantly enhanced by all three precursors, overview
Plectranthus scutellarioides
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Plectranthus scutellarioides
-
-
-
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
L-tyrosine
activates the enzyme
Plectranthus scutellarioides
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
cultures fed with precursors, namely L-Phe, L-Tyr, and cucumber juice, at different concentrations show Phe an 1.5, 2.1, and 1.6fold increase in rosmarinic acid accumulation within 48-72 h, respectively. In this study, we focused on the function of individual precursor on key enzymes involved in RA biosynthesis. The phenylalanine ammonia lyase activity was significantly upregulated after Phe feeding, while tyrosine aminotransferase and hydroxyphenylpyruvate reductase activities are improved with Tyr treatment. Rosmarinic acid synthase activity is significantly enhanced by all three precursors, overview
Plectranthus scutellarioides
General Information
General Information
Commentary
Organism
metabolism
the key enzyme is involved in rosmarinic acid biosynthesis
Plectranthus scutellarioides
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the key enzyme is involved in rosmarinic acid biosynthesis
Plectranthus scutellarioides
Other publictions for EC 1.1.1.237
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741036
Battini
Rhizophagus intraradices or it ...
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1
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1
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1
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1
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2
1
1
2
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-
739156
Kim
Molecular cloning and characte ...
Scutellaria baicalensis
Nat. Prod. Commun.
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1
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1
1
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741057
Dewanjee
Enhanced rosmarinic acid biosy ...
Plectranthus scutellarioides
Nat. Prod. Res.
28
1691-1698
2014
1
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1
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3
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Lu
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Perilla frutescens
Proc. 2012 Int. Conf. Appl. Biotechnol.
251 LNEE
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Salvia miltiorrhiza
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2013
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Fujii
Novel fungal phenylpyruvate re ...
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Biochim. Biophys. Acta
1814
1669-1676
2011
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Structure and substrate dockin ...
Plectranthus scutellarioides
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2010
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Qian
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Kim
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Plectranthus scutellarioides
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286349
Petersen
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Two new enzymes of rosmarinic ...
Plectranthus scutellarioides
Z. Naturforsch. C
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501-504
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2
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