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Literature summary for 1.1.1.230 extracted from

  • Akao, T.; Akao, T.; Hattori, M.; Namba, T.; Kobashi, K.
    Purification and properties of 3alpha-hydroxyglycyrrhetinate dehydrogenase of Clostridium innocuum from human intestine (1988), J. Biochem., 103, 504-507.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00027
-
NADP+
-
[Clostridium] innocuum
0.001
-
3-Ketoglycyrrhetic acid
-
[Clostridium] innocuum
0.002
-
3alpha-Hydroxyglycyrrhetic acid
-
[Clostridium] innocuum
0.024
-
NADPH
-
[Clostridium] innocuum

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
[Clostridium] innocuum
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
2 * 30000, SDS-PAGE [Clostridium] innocuum
53000
-
gel filtration [Clostridium] innocuum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3alpha-hydroxyglycyrrhetic acid + NADP+ [Clostridium] innocuum oxidation of 3alpha-hydroxy group faster than reduction of 3-keto group 3-ketoglycyrrhetic acid + NADPH
-
r

Organism

Organism UniProt Comment Textmining
[Clostridium] innocuum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
[Clostridium] innocuum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-hydroxy-18alpha-glycyrrhetic acid + NADP+
-
[Clostridium] innocuum 3-keto-18alpha-glycyrrhetic acid + NADPH
-
r
3alpha-hydroxyglycyrrhetic acid + NADP+ oxidation of 3alpha-hydroxy group faster than reduction of 3-keto group, not accepted as substrates: 3beta-hydroxyglycyrrhetic acid, steroids or bile acids containing 3alpha-hydroxy or 3-keto group [Clostridium] innocuum 3-ketoglycyrrhetic acid + NADPH
-
r
3alpha-hydroxyglycyrrhetic acid + NADP+ oxidation of 3alpha-hydroxy group faster than reduction of 3-keto group [Clostridium] innocuum 3-ketoglycyrrhetic acid + NADPH
-
r

Subunits

Subunits Comment Organism
dimer 2 * 30000, SDS-PAGE [Clostridium] innocuum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
reduction of 3-keto group [Clostridium] innocuum
8
-
oxidation of 3alpha-hydroxy group [Clostridium] innocuum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
[Clostridium] innocuum
NADPH
-
[Clostridium] innocuum