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Literature summary for 1.1.1.23 extracted from

  • Adams, E.
    The enzymatic synthesis of histidine from histidinol (1954), J. Biol. Chem., 209, 829-846.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Borate 10 mM, 90% inhibition Paenarthrobacter histidinolovorans
EDTA 30 mM, 50% inhibition at pH 7.5 Paenarthrobacter histidinolovorans
p-chloromercuribenzoate 0.02 mM, 50% inhibition Paenarthrobacter histidinolovorans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
NAD+
-
Paenarthrobacter histidinolovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidinal + NAD+ + H2O Escherichia coli reaction intermediate L-histidine + NADH + H+
-
?
L-histidinal + NAD+ + H2O Paenarthrobacter histidinolovorans reaction intermediate L-histidine + NADH + H+
-
?
L-histidinol + 2 NAD+ + H2O Escherichia coli
-
L-histidine + 2 NADH + 2 H+
-
?
L-histidinol + 2 NAD+ + H2O Paenarthrobacter histidinolovorans
-
L-histidine + 2 NADH + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Paenarthrobacter histidinolovorans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidinal + NAD+ + H2O
-
Escherichia coli L-histidine + NADH + H+
-
?
L-histidinal + NAD+ + H2O
-
Paenarthrobacter histidinolovorans L-histidine + NADH + H+
-
?
L-histidinal + NAD+ + H2O reaction intermediate Escherichia coli L-histidine + NADH + H+
-
?
L-histidinal + NAD+ + H2O reaction intermediate Paenarthrobacter histidinolovorans L-histidine + NADH + H+
-
?
L-histidinol + 2 NAD+ + H2O
-
Escherichia coli L-histidine + 2 NADH + 2 H+
-
?
L-histidinol + 2 NAD+ + H2O
-
Paenarthrobacter histidinolovorans L-histidine + 2 NADH + 2 H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
crude extracts Escherichia coli
8.7
-
partly purified enzyme Paenarthrobacter histidinolovorans

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli
NAD+
-
Paenarthrobacter histidinolovorans