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Literature summary for 1.1.1.228 extracted from

  • Dehal, S.S.; Croteau, R.
    Metabolism of monoterpenes: Specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3-thujone, and 3-isothujone (1987), Arch. Biochem. Biophys., 258, 287-291.
    View publication on PubMed

General Stability

General Stability Organism
stable to lyophilization Salvia officinalis
stable to lyophilization Tanacetum vulgare

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
gel filtration Tanacetum vulgare
92000
-
gel filtration Salvia officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-cis-sabinol + NAD+ Salvia officinalis pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) (+)-sabinone + NADH
-
?
(+)-cis-sabinol + NAD+ Tanacetum vulgare pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) (+)-sabinone + NADH
-
?

Organism

Organism UniProt Comment Textmining
Salvia officinalis
-
sage
-
Tanacetum vulgare
-
tansy
-

Purification (Commentary)

Purification (Comment) Organism
partial Salvia officinalis
partial Tanacetum vulgare

Source Tissue

Source Tissue Comment Organism Textmining
leaf epidermis oil glands Salvia officinalis
-
leaf epidermis oil glands Tanacetum vulgare
-

Storage Stability

Storage Stability Organism
-40°C, lyophilized, under argon, stable for several months without deterioration Salvia officinalis
-40°C, lyophilized, under argon, stable for several months without deterioration Tanacetum vulgare

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cis-sabinol + NAD+
-
Salvia officinalis (+)-sabinone + NADH
-
?
(+)-cis-sabinol + NAD+
-
Tanacetum vulgare (+)-sabinone + NADH
-
?
(+)-cis-sabinol + NAD+ pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) Salvia officinalis (+)-sabinone + NADH
-
?
(+)-cis-sabinol + NAD+ pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) Tanacetum vulgare (+)-sabinone + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
additional information flavin nucleotides are ineffective Salvia officinalis
additional information flavin nucleotides are ineffective Tanacetum vulgare
NAD+
-
Salvia officinalis
NAD+
-
Tanacetum vulgare
NADP+ 65-85% as effective as NAD+ Salvia officinalis
NADP+ 65-85% as effective as NAD+ Tanacetum vulgare