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Literature summary for 1.1.1.225 extracted from
- Purification and characterization of chlordecone reductase from human liver (1986), J. Biol. Chem., 261, 12624-12627.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | slight inhibition | Homo sapiens |  |
| Cu2+ | slight inhibition | Meriones unguiculatus | |
| Ethacrynic acid | - |
Homo sapiens | |
| Ethacrynic acid | - |
Meriones unguiculatus | |
| Hg2+ | slight inhibition | Homo sapiens | |
| Hg2+ | slight inhibition | Meriones unguiculatus | |
| indomethacin | - |
Homo sapiens | |
| indomethacin | - |
Meriones unguiculatus | |
| additional information | not inhibited by phenobarbital | Homo sapiens | |
| additional information | not inhibited by phenobarbital | Meriones unguiculatus | |
| p-chloromercuribenzoate | - |
Homo sapiens | |
| p-chloromercuribenzoate | - |
Meriones unguiculatus | |
| quercetin | - |
Homo sapiens | |
| quercetin | - |
Meriones unguiculatus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
Chlordecone | - |
Homo sapiens | |
| 0.003 | - |
Chlordecone | - |
Meriones unguiculatus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
| cytoplasm | - |
Meriones unguiculatus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Meriones unguiculatus | - |
- |
- |
| no activity in Mesocricetus auratus | - |
- |
- |
| no activity in Mus musculus | - |
- |
- |
| no activity in Rattus norvegicus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Meriones unguiculatus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.008 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 50% glycerol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | - |
Homo sapiens | chlordecone alcohol + NADP+ | - |
? | |
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | - |
Oryctolagus cuniculus | chlordecone alcohol + NADP+ | - |
? | |
| 1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH | - |
Meriones unguiculatus | chlordecone alcohol + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
2 optima: pH 7.5 and 9.0 | Homo sapiens |
| 9 | - |
2 optima: pH 7.5 and 9.0 | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no activity with NADH | Homo sapiens | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Oryctolagus cuniculus | |
| NADPH | - |
Meriones unguiculatus | |
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