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Literature summary for 1.1.1.220 extracted from

  • Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.
    Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase (1989), Biochem. Biophys. Res. Commun., 164, 1130-1136.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyltetrahydropterin + NADPH Homo sapiens involved in de novo biosynthesis of tetrahydrobiopterin 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 enzyme is identical to aldose reductase
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrobenzaldehyde + NADPH
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 Homo sapiens 4-nitrobenzylalcohol + NADP+
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 ?
6-pyruvoyltetrahydropterin + NADPH
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 Homo sapiens 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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 ?
6-pyruvoyltetrahydropterin + NADPH involved in de novo biosynthesis of tetrahydrobiopterin Homo sapiens 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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 ?
additional information typical substrates of aldose reductase tested as substrates Homo sapiens ?
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 ?