Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.220 extracted from

  • Milstien, S.; Kaufman, S.
    Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates (1985), Biochem. Biophys. Res. Commun., 128, 1099-1107.
    View publication on PubMed
Search for more literature for 1.1.1.220

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyltetrahydropterin + NADPH Rattus norvegicus involved in de novo biosynthesis of tetrahydrobiopterin 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?
6-pyruvoyltetrahydropterin + NADPH Bos taurus involved in de novo biosynthesis of tetrahydrobiopterin 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from brain Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000159
-
-
 Bos taurus
0.000021
-
 liver Rattus norvegicus
0.0000514
-
 brain Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyltetrahydropterin + NADPH
-
 Rattus norvegicus 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?
6-pyruvoyltetrahydropterin + NADPH
-
 Bos taurus 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?
6-pyruvoyltetrahydropterin + NADPH involved in de novo biosynthesis of tetrahydrobiopterin Rattus norvegicus 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?
6-pyruvoyltetrahydropterin + NADPH involved in de novo biosynthesis of tetrahydrobiopterin Bos taurus 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
 ?