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Literature summary for 1.1.1.211 extracted from

  • Khare, T.; Khare, S.; Angdisen, J.J.; Zhang, Q.; Stuckel, A.; Mooney, B.P.; Ridenhour, S.E.; Gitan, R.S.; Hammoud, G.M.; Ibdah, J.A.
    Defects in long-chain 3-hydroxy acyl-CoA dehydrogenase lead to hepatocellular carcinoma A novel etiology of hepatocellular carcinoma (2020), Int. J. Cancer, 147, 1461-1473 .
    View publication on PubMed
Search for more literature for 1.1.1.211

Organism

Organism UniProt Comment Textmining
Homo sapiens P40939
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-
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
-
 Homo sapiens
-
liver
-
 Mus musculus
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liver
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HADHA
-
 Homo sapiens
LCHAD
-
 Mus musculus
LCHAD
-
 Homo sapiens
long-chain 3-hydroxy acyl-CoA dehydrogenase
-
 Mus musculus
long-chain 3-hydroxy acyl-CoA dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens in hepatocarcinoma, there is a significant downregulation of enzyme transcripts as compared to controls down

General Information

General Information Comment Organism
malfunction defects in long-chain 3-hydroxy acyl-CoA dehydrogenase lead to hepatocellular carcinoma Homo sapiens
malfunction enzyme exon 15 deletion is embryonic lethal to the homozygous mice whereas heterozygous mice develop significant hepatic steatosis starting at young age (3 months old) and hepatocellular carcinoma at older age (more than13 months old) without any evidence of fibrosis or cirrhosis Mus musculus