Literature summary for 1.1.1.21 extracted from

Khan, M.S.; Qais, F.A.; Rehman, M.T.; Ismail, M.H.; Alokail, M.S.; Altwaijry, N.; Alafaleq, N.O.; AlAjmi, M.F.; Salem, N.; Alqhatani, R.
Mechanistic inhibition of non-enzymatic glycation and aldose reductase activity by naringenin Binding, enzyme kinetics and molecular docking analysis (2020), Int. J. Biol. Macromol., 159, 87-97 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
naringenin	uncompetitive. The interaction is enthalpy driven and the microenvironment of aromatic residues is also altered. Naringenin inhibits fructosamine content by approximately 31.6% at 0.01 mM, and more than 93% inhibition of fluorescent advanced glycation end-products is achieved. Naringenin forms hydrogen bonds (Asn160 and Ile260), and two Pi-Pi interactions with Trp20 and one with His110	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0026	-	pH 6.2, 25°C	Homo sapiens	naringenin

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Release 2023.1 (January 2023)