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Literature summary for 1.1.1.21 extracted from

  • Rivelli, J.F.; Ochoa, A.L.; Santander, V.S.; Nigra, A.; Previtali, G.; Casale, C.H.
    Regulation of aldose reductase activity by tubulin and phenolic acid derivates (2018), Arch. Biochem. Biophys., 654, 19-26 .
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxyphenylacetic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
3-hydroxy-4-methoxymandelic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
3-nitro-L-tyrosine able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
4-hydroxy-3-methoxymandelic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
4-hydroxy-3-methoxyphenylacetic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
4-hydroxy-3-methoxyphenyllactic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
L-tyrosine able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens
vanillic acid able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
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-

General Information

General Information Comment Organism
physiological function aldose reductase interacts directly with tubulin and has greater affinity for 3-nitro-tyrosinated tubulin. Free 3-nitro-Tyr or Tyr prevents tubulin/aldose reductase complex formation and aldose reductase activation. The induction of microtubule formation by high concentrations of glucose and the consequent activation of aldose reductase in cultured cells can be inhibited by phenolic acid derivates that prevent the interaction tubulin/aldose reductase Homo sapiens