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Literature summary for 1.1.1.21 extracted from

  • Qiu, L.; Lin, J.; Ying, M.; Chen, W.; Yang, J.; Deng, T.; Chen, J.; Shi, D.; Yang, J.Y.
    Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis (2013), PLoS ONE, 8, e73591.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene AKR1B1, quantitative real-time PCR enzyme expression analysis, recombinant expression of FLAG-tagged enzyme in AML12 cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Mus musculus
-

Synonyms

Synonyms Comment Organism
aldose reductase
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockdown reduces the development of diet-induced liver fibrosis Mus musculus
physiological function aldose reductase catalyzes the rate-limiting reduction of glucose to sorbitol with the aid of cofactor NADPH. The enzyme induces elevations on the level of CYP2E1 expression, reactive oxygen species, mRNA expression of TNF-alpha, and IL-6, confirmed in AML12 hepatocytes. The enzyme is involved in the development of methionine-choline-deficient diet-induced steatohepatitis in diabetic db/db mice, and plays a role in the development of diabetic complications. The enzyme alleviates the diet-induced (via methionine-choline-deficient (MCD) diet) liver inflammation and fibrosis in db/db mice, probably through dampening CYP2E1 mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines Mus musculus