Cloned (Comment) | Organism |
---|---|
gene AKR1B1, quantitative real-time PCR enzyme expression analysis, recombinant expression of FLAG-tagged enzyme in AML12 cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown reduces the development of diet-induced liver fibrosis | Mus musculus |
physiological function | aldose reductase catalyzes the rate-limiting reduction of glucose to sorbitol with the aid of cofactor NADPH. The enzyme induces elevations on the level of CYP2E1 expression, reactive oxygen species, mRNA expression of TNF-alpha, and IL-6, confirmed in AML12 hepatocytes. The enzyme is involved in the development of methionine-choline-deficient diet-induced steatohepatitis in diabetic db/db mice, and plays a role in the development of diabetic complications. The enzyme alleviates the diet-induced (via methionine-choline-deficient (MCD) diet) liver inflammation and fibrosis in db/db mice, probably through dampening CYP2E1 mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines | Mus musculus |