Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fidarestat | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha and vascular endothelial growth factor by regulating 26 S proteasome-mediated protein degradation in colon cancer cells, molecular mechanism, overview. Inhibition of hypoxia-induced HIF-1 protein accumulation by enzyme inhibition is abolished in the presence of MG132, a potent inhibitor of the 26 S proteasome. Enzyme inhibition also prevents the hypoxia-induced inflammatory molecules such as Cox-2 and PGE2 and expression of extracellular matrix proteins such as MMP2, vimentin, uPAR, and lysyl oxidase 2, overview | Homo sapiens |
physiological function | the enzyme in involved in the hypoxia-induced colon cancer cells growth and invasion, overview | Homo sapiens |