Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fidarestat | aldose reductase inhibitor, attenuates the increase in growth, but in the absence of angiogenic factors, such as VEGF- and FGF, fidarestat alone does not affect the HUVEC growth | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
HUVEC cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition prevents human colon cancer cell growth in culture as well as in nude mice xenografts. Inhibition of the enzyme also prevents angiogenic factors-induced invasion and migration of human umbilical vein endothelial cells and angiogenic factors-induced secretion/expression of ICAM, VCAM, MMP2, MMP9 and IL-6 in the cells, mechanisms, overview | Homo sapiens |
physiological function | the enzyme is involved in oxidative stress signaling, it mediates colon cancer cell growth and proliferation involving angiogenic factors, such as VEGF- and FGF, overview | Homo sapiens |