Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fidarestat | - |
Homo sapiens | |
additional information | inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue | Homo sapiens | |
sorbinil | - |
Homo sapiens | |
zopolrestat | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
DL-glycerol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | DL-glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue | down |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in colon cancer cells. Inhibition of aldose reductasee prevents EGF- and bFGF-induced DNA binding activity and expression of E2F-1 in colon cancer cells, overview | Homo sapiens |