Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zopolrestat | treatment with the aldose reductase inhibitor zopolrestat significantly improves endothelial-dependent relaxation in response to acetylcholine in aged rats | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Fischer 344 rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | aortic, higher activity in aged compared to young rats | Rattus norvegicus | - |
smooth muscle cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | upregulation of the aldose reductase pathway with aging | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme and AGE-RAGE pathways, involving advanced glycation endproducts and their a soluble form of the chief signal transduction receptors, play central roles in the pathogenesis of vascular dysfunction in aging rats. Significant increases in aldose reductase expression and activity in aged rat vasculature linked to endothelial dysfunction may be mitigated, at least in part, via aldose reductase inhibitors and that aging-linked increased flux via aldose reductase generates advanced glycation endproducts, species which transduce endothelial injury consequent to their interaction with RAGE, the soluble form of the chief signal transduction receptors of advanced glycation products | Rattus norvegicus |