Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 (DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
butein | 89.9% inhibition at 0.002 mM | Homo sapiens | |
epalrestat | 85.8% inhibition at 0.0025 mM | Homo sapiens | |
fisetin | 31.1% inhibition at 0.002 mM | Homo sapiens | |
fustin | 20.1% inhibition at 0.002 mM | Homo sapiens | |
Morin hydrate | 14.1% inhibition at 0.002 mM | Homo sapiens | |
pentagalloyl glucose | 46.6% inhibition at 0.002 mM | Homo sapiens | |
protocatechuic acid | 12.6% inhibition at 0.002 mM | Homo sapiens | |
quercetin | 39.1% inhibition at 0.002 mM | Homo sapiens | |
sulfuretin | 69.8% inhibition at 0.002 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alditol/NADP+ oxidoreductase | - |
Homo sapiens |
aldose reductase | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0007 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | butein | |
0.0013 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | epalrestat | |
0.0013 | - |
in 0.1 M sodium phosphate buffer (pH 6.2) | Homo sapiens | sulfuretin |