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Literature summary for 1.1.1.21 extracted from

  • Lee, E.H.; Song, D.G.; Lee, J.Y.; Pan, C.H.; Um, B.H.; Jung, S.H.
    Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts (2008), Biol. Pharm. Bull., 31, 1626-1630.
    View publication on PubMed
Search for more literature for 1.1.1.21

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
butein 89.9% inhibition at 0.002 mM Homo sapiens
epalrestat 85.8% inhibition at 0.0025 mM Homo sapiens
fisetin 31.1% inhibition at 0.002 mM Homo sapiens
fustin 20.1% inhibition at 0.002 mM Homo sapiens
Morin hydrate 14.1% inhibition at 0.002 mM Homo sapiens
pentagalloyl glucose 46.6% inhibition at 0.002 mM Homo sapiens
protocatechuic acid 12.6% inhibition at 0.002 mM Homo sapiens
quercetin 39.1% inhibition at 0.002 mM Homo sapiens
sulfuretin 69.8% inhibition at 0.002 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
alditol/NADP+ oxidoreductase
-
 Homo sapiens
aldose reductase
-
 Homo sapiens
ALR2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0007
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens butein
0.0013
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens epalrestat
0.0013
-
 in 0.1 M sodium phosphate buffer (pH 6.2) Homo sapiens sulfuretin