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Literature summary for 1.1.1.21 extracted from

  • Endo, S.; Matsunaga, T.; Mamiya, H.; Ohta, C.; Soda, M.; Kitade, Y.; Tajima, K.; Zhao, H.T.; El-Kabbani, O.; Hara, A.
    Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids (2009), Arch. Biochem. Biophys., 487, 1-9.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells and in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17alpha-estradiol
-
Homo sapiens
17beta-estradiol
-
Homo sapiens
4-androsten-17alpha-ol-3-one i.e. epitestosterone Homo sapiens
4-androsten-17beta-ol-3-one i.e. testosterone Homo sapiens
4-androstene-3,17-dione
-
Homo sapiens
4-pregenene-21-ol-3,20-dione i.e. 11-deoxycorticosterone Homo sapiens
4-pregnene-11beta,17alpha,21-triol-3,20-dione i.e. cortisol Homo sapiens
4-pregnene-11beta,21-diol-3,20-dione i.e. corticosterone Homo sapiens
4-pregnene-17alpha,21-diol-3,11,20-trione i.e. cortisone Homo sapiens
4-pregnene-18-al-11beta,21-diol-3,20-dione i.e. aldosteron Homo sapiens
5-androsten-3beta-ol-17-one i.e. dehydroepiandrosterone Homo sapiens
5-cholenic acid-3beta-ol
-
Homo sapiens
5alpha-Androstan-17alpha-ol-3-one
-
Homo sapiens
5alpha-androstan-17beta-ol-3-one i.e. 5alpha-dehydrotestosterone Homo sapiens
5alpha-Androstan-3alpha-ol-17-one
-
Homo sapiens
5alpha-Androstan-3beta-ol-17-one competitive inhibition with respect to geraniol Homo sapiens
5alpha-androstane-3,17-dione competitive inhibition with respect to geraniol Homo sapiens
5alpha-androstane-3alpha,17beta-diol
-
Homo sapiens
5alpha-Androstane-3beta,17beta-diol
-
Homo sapiens
5alpha-cholanic acid-3beta-ol
-
Homo sapiens
5alpha-pregnan-3beta-ol-20-one
-
Homo sapiens
5alpha-pregnane-21-ol-3,20-dione
-
Homo sapiens
5alpha-pregnane-3,20-dione competitive inhibition with respect to geraniol Homo sapiens
5beta-androstan-17beta-ol-3-one
-
Homo sapiens
5beta-Androstan-3alpha-ol-17-one
-
Homo sapiens
5beta-androstan-3beta-ol-17-one
-
Homo sapiens
5beta-androstane-3,17-dione
-
Homo sapiens
5beta-androstane-3beta,17beta-diol
-
Homo sapiens
5beta-cholan-24-ol
-
Homo sapiens
5beta-cholanic acid competitive inhibition with respect to geraniol Homo sapiens
5beta-cholanic acid methyl ester
-
Homo sapiens
5beta-cholanic acid-3-one
-
Homo sapiens
5beta-cholanic acid-3alpha,12alpha-diol i.e. chenodeoxycholic acid Homo sapiens
5beta-cholanic acid-3alpha,6alpha-diol i.e. hyodeoxycholic acid Homo sapiens
5beta-cholanic acid-3alpha,7alpha,12alpha-triol i.e. cholic acid Homo sapiens
5beta-cholanic acid-3alpha,7alpha-diol i.e. deoxycholic acid Homo sapiens
5beta-cholanic acid-3alpha,7beta-diol i.e. ursodeoxycholic acid Homo sapiens
5beta-cholanic acid-3alpha-ol i.e. lithocholic acid Homo sapiens
5beta-cholanic acid-3beta-ol i.e. isolithocholic acid Homo sapiens
5beta-Pregnan-3alpha-ol-20-one
-
Homo sapiens
5beta-Pregnan-3beta-ol-20-one
-
Homo sapiens
5beta-pregnane-3,20-dione
-
Homo sapiens
Cibacron blue F3GA competitive inhibition with respect to NADP+, noncompetitive inhibition with respect to geraniol Homo sapiens
estriol i.e. 16alpha-hydroxyestradiol Homo sapiens
estrone
-
Homo sapiens
glycochenodeoxycholic acid
-
Homo sapiens
glycolithocholic acid competitive inhibition with respect to geraniol Homo sapiens
isolithocholic acid uncompetitive inhibition with respect to NADP+, competitive inhibition with respect to geraniol Homo sapiens
lithocholic acid competitive inhibition with respect to geraniol Homo sapiens
Tolrestat uncompetitive inhibition with respect to NADP+, competitive inhibition with respect to geraniol Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
5-Pregnene-3beta,20alpha-diol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0004
-
geranylgeraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0004
-
5alpha-pregnan-20alpha-ol-3-one in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0006
-
1-Tetradecanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0007
-
1-nonanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0008
-
5alpha-pregnane-3beta,20alpha-diol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0009
-
20alpha-hydroxyprogesterone in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0009
-
geranylgeraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0017
-
1-octanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0022
-
isatin in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0023
-
trans,trans-farnesol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0026
-
1-Dodecanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0027
-
1-heptanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0032
-
21-Dehydrocortisol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0033
-
trans,trans-farnesol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0034
-
trans-2-nonen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.004
-
trans-2-decen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0044
-
1-Decanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.0097
-
benzaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.011
-
1-nonanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.02
-
nerol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.025
-
geraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.028
-
trans-2-hexen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.051
-
2,3-Hexanedione in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.056
-
isocaproaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.091
-
1-butanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.112
-
1-hexanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.129
-
3-deoxyglucosone in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.13
-
Pyridine-3-aldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.18
-
1-Hexanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.25
-
trans-2-buten-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.3
-
benzyl alcohol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.49
-
Pyridine-3-methanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.74
-
D-lactoaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
11
-
Glyoxal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
21
-
glycolaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60218
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-charged Sepharose resin column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-butanal + NADPH + H+
-
Homo sapiens butanol + NADP+
-
?
1-decanol + NADP+
-
Homo sapiens decanal + NADPH + H+
-
?
1-dodecanal + NADPH + H+
-
Homo sapiens dodecanol + NADP+
-
?
1-heptanal + NADPH + H+
-
Homo sapiens heptanol + NADP+
-
?
1-hexanal + NADPH + H+
-
Homo sapiens hexanol + NADP+
-
?
1-nonanal + NADPH + H+
-
Homo sapiens nonanol + NADP+
-
?
1-nonanol + NADP+
-
Homo sapiens nonanal + NADPH + H+
-
?
1-tetradecanol + NADP+
-
Homo sapiens tetradecanal + NADPH + H+
-
?
2,3-hexanedione + NADPH + H+
-
Homo sapiens ?
-
?
20alpha-hydroxyprogesterone + NADPH + H+
-
Homo sapiens ?
-
?
21-dehydrocortisol + NADPH + H+
-
Homo sapiens ?
-
?
3-deoxyglucosone + NADPH + H+
-
Homo sapiens ?
-
?
5-pregnene-3beta,20alpha-diol + NADPH
-
Homo sapiens ?
-
?
5alpha-pregnan-20alpha-ol-3-one + NADPH + H+
-
Homo sapiens ?
-
?
5alpha-pregnane-3beta,20alpha-diol + NADPH + H+
-
Homo sapiens ?
-
?
benzaldehyde + NADPH + H+
-
Homo sapiens benzyl alcohol + NADP+
-
?
D-lactaldehyde + NADPH + H+
-
Homo sapiens ?
-
?
farnesal + NADPH + H+ specific substrate Homo sapiens trans,trans-farnesol + NADP+
-
?
geraniol + NADP+
-
Homo sapiens geranial + NADPH + H+
-
?
geranylgeranial + NADPH + H+ specific substrate Homo sapiens geranylgeraniol + NADP+
-
?
glycolaldehyde + NADPH + H+
-
Homo sapiens ?
-
?
glyoxal + NADPH + H+
-
Homo sapiens ?
-
?
isatin + NADPH + H+ specific substrate Homo sapiens 3-hydroxyisatin + NADP+
-
?
isocaproaldehyde + NADPH + H+
-
Homo sapiens ?
-
?
additional information AKR1B10 does not reduce D-glucose Homo sapiens ?
-
?
nerol + NADPH + H+
-
Homo sapiens ?
-
?
octanal + NADPH + H+
-
Homo sapiens octanol + NADP+
-
?
pyridine-3-aldehyde + NADPH + H+
-
Homo sapiens 3-pyridinemethanol + NADP+
-
?
pyridine-3-methanol + NADP+
-
Homo sapiens ?
-
?
trans-2-buten-1-al + NADPH + H+
-
Homo sapiens ?
-
?
trans-2-decen-1-al + NADPH + H+
-
Homo sapiens ?
-
?
trans-2-hexen-1-al + NADPH + H+
-
Homo sapiens ?
-
?
trans-2-nonen-1-al + NADPH + H+
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AKR1B10
-
Homo sapiens
aldose reductase-like protein
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.004
-
20alpha-hydroxyprogesterone in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.006
-
5-Pregnene-3beta,20alpha-diol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.008
-
5alpha-pregnan-20alpha-ol-3-one in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.012
-
5alpha-pregnane-3beta,20alpha-diol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.017
-
1-Tetradecanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.042
-
Pyridine-3-methanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.05
-
1-Decanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.065
-
1-nonanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.078
-
geranylgeraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.117
-
nerol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.155
-
trans,trans-farnesol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.158
-
1-Hexanol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.165
-
geranylgeraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.167
-
benzyl alcohol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.48
-
21-Dehydrocortisol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.5
-
trans,trans-farnesol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.567
-
geraniol in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.58
-
glycolaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.75
-
3-deoxyglucosone in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.78
-
trans-2-buten-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
0.82
-
trans-2-hexen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.12
-
isatin in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.12
-
Glyoxal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.25
-
1-Dodecanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.3
-
1-butanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.32
-
2,3-Hexanedione in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.34
-
trans-2-nonen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.37
-
1-octanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.38
-
1-nonanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.43
-
isocaproaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.73
-
benzaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.83
-
trans-2-decen-1-al in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
1.87
-
D-lactoaldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
2
-
1-heptanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
2.37
-
1-hexanal in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens
2.5
-
Pyridine-3-aldehyde in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 10 using 0.1 mM geraniol as substrate Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000027
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3beta-ol
0.000052
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid
0.000064
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-cholanic acid-3beta-ol
0.00011
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3-one
0.00012
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha-ol
0.00021
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha,12alpha-diol
0.00023
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5-cholenic acid-3beta-ol
0.00026
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha,6alpha-diol
0.00032
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-Androstan-3beta-ol-17-one
0.00033
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-androstan-3beta-ol-17-one
0.00037
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-pregnane-21-ol-3,20-dione
0.00039
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-androstane-3,17-dione
0.00044
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-pregnane-3,20-dione
0.00044
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-Pregnan-3beta-ol-20-one
0.0005
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-androstene-3,17-dione
0.0005
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-pregnan-3beta-ol-20-one
0.00051
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-androstan-17beta-ol-3-one
0.00052
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-Androstane-3beta,17beta-diol
0.00055
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-Pregnan-3alpha-ol-20-one
0.00071
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens glycolithocholic acid
0.00078
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-pregnane-3,20-dione
0.00078
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha,7beta-diol
0.0011
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5-androsten-3beta-ol-17-one
0.0011
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha,7alpha-diol
0.0016
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens estrone
0.0016
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-androstane-3beta,17beta-diol
0.0016
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-androsten-17beta-ol-3-one
0.0021
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-androstane-3,17-dione
0.0022
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid-3alpha,7alpha,12alpha-triol
0.0022
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-pregnene-17alpha,21-diol-3,11,20-trione
0.0025
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-pregenene-21-ol-3,20-dione
0.0027
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-Androstan-3alpha-ol-17-one
0.003
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 17beta-estradiol
0.0033
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens (17alpha)-17-hydroxyandrost-4-en-3-one
0.0042
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-androstan-17beta-ol-3-one
0.0046
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-androstane-3alpha,17beta-diol
0.0048
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-Androstan-3alpha-ol-17-one
0.005
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-pregnene-11beta,21-diol-3,20-dione
0.0057
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5alpha-Androstan-17alpha-ol-3-one
0.0071
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens glycochenodeoxycholic acid
0.012
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 17alpha-estradiol
0.017
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-pregnene-11beta,17alpha,21-triol-3,20-dione
0.018
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholanic acid methyl ester
0.022
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 4-pregnene-18-al-11beta,21-diol-3,20-dione
0.025
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens estriol
0.04
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C Homo sapiens 5beta-cholan-24-ol