Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-tetradecanoylphorbol-13-acetate | i.e. TPA, induces enzyme expression in A-549 cells and increases the enzyme activity, TPA is a potent tumor promoter, TPA-induced increase in mRNA level and promoter activity of the AR gene is significantly attenuated in the presence of inhibitors of protein kinase C, tyrosine kinase, or nuclear kinase and NF- kB, cycloheximide, actinomycin D, bisindolylmaleimide I, and genistein abolish enzyme induction by TPA | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | inhibition of AR may assist in the chemotherapy of malignant tumors by suppressing the rapid growth of cancer cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate | an AR inhibitor, abolishes the accumulation of TPA-treated cells in S phase was almost completely | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
? | |
additional information | Homo sapiens | the enzyme may serve as an extrahepatic detoxification enzyme against endogenous and xenobiotic aldehydes in various tissues or cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | lung adenocarcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
additional information | the enzyme may serve as an extrahepatic detoxification enzyme against endogenous and xenobiotic aldehydes in various tissues or cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
AR | - |
Homo sapiens |
More | the enzyme belongs to the NADPH-dependent aldo-keot reductase family | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |