Application | Comment | Organism |
---|---|---|
medicine | inhibition of enzyme by tolrestat or sorbinil prevents apotosis and activation of calpase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C, but does not prevent the activation of transkription factor NK-kappaB and protein kinase C by phorbol ester, enzyme is an obligatory mediator of the apoptotic events upstream of protein kinase C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | inhibition of enzyme, preventing apotosis and activation of caspase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C | Homo sapiens | |
Tolrestat | inhibition of enzyme, preventing apotosis and activation of caspase-3, attenuation of TNF-alpha and hyperglykemia-induced activation of protein kinase C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HLE B-3 cell | lens epithelial cell line | Homo sapiens | - |