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Literature summary for 1.1.1.21 extracted from

  • Hayman, S.; Kinoshita, J.H.
    Isolation and properties of lens aldose reductase (1965), J. Biol. Chem., 240, 877-882.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Oxodecanoate
-
Bos taurus
2-oxoglutarate
-
Bos taurus
2-Oxoheptanoate
-
Bos taurus
2-Oxohexanoate
-
Bos taurus
2-Oxoisohexanoate
-
Bos taurus
2-oxoisopentanoate
-
Bos taurus
2-oxononanoate
-
Bos taurus
2-oxooctanoate
-
Bos taurus
2-oxopentanoate
-
Bos taurus
3-hydroxybutyrate
-
Bos taurus
acetoacetate
-
Bos taurus
ammonium acetate
-
Bos taurus
NaCl
-
Bos taurus
Octanoate
-
Bos taurus
oxaloacetate
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
Isobutyraldehyde
-
Bos taurus
0.03
-
DL-glyceraldehyde
-
Bos taurus
0.4
-
D-erythrose
-
Bos taurus
0.7
-
D-glucuronolactone
-
Bos taurus
2
-
D-xylose
-
Bos taurus
4
-
D-glucuronate
-
Bos taurus
5
-
D-glucuronate
-
Bos taurus
7
-
D-ribose
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
calf
-

Purification (Commentary)

Purification (Comment) Organism
calf Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
aldose + NAD(P)H wide specificity Bos taurus alditol + NAD(P)+
-
r
D-erythrose + NAD(P)H
-
Bos taurus erythritol + NAD(P)+
-
?
D-glucuronate + NAD(P)H
-
Bos taurus ?
-
r
D-glucuronolactone + NADPH
-
Bos taurus ?
-
?
D-ribose + NAD(P)H
-
Bos taurus ribitol + NAD(P)+
-
r
D-xylose + NAD(P)H
-
Bos taurus xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Bos taurus glycerol + NAD(P)+
-
r
isobutyraldehyde + NADPH + H+
-
Bos taurus isobutanol + NADP+
-
?
xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r