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Literature summary for 1.1.1.21 extracted from

  • O'Brien, M.M.; Schofield, P.J.
    Polyol-pathway enzymes of human brain. Partial purification and properties of aldose reductase and hexonate dehydrogenase (1980), Biochem. J., 187, 21-30.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
5,5-diphenylhydantoin
-
 Homo sapiens
Barbital
-
 Homo sapiens
Ethosuccinimide
-
 Homo sapiens
NADP+
-
 Homo sapiens
Phenobarbitone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
 alditol + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10.2
-
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 4 weeks, little loss of activity Homo sapiens
4°C, 3 weeks, 50% loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
 Homo sapiens aldose + NAD(P)H
-
 r
aldose + NAD(P)H
-
 Homo sapiens alditol + NAD(P)+
-
 r
D-glucose + NAD(P)H
-
 Homo sapiens sorbitol + NAD(P)+
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
 DL-glyceraldehyde + NADPH Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 7.5 at pH 5.5 and pH 7.5 about 50% of activity maximum Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens