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Literature summary for 1.1.1.21 extracted from

  • Das, B.; Srivastava, S.K.
    Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte (1985), Arch. Biochem. Biophys., 238, 670-679.
    View publication on PubMed

General Stability

General Stability Organism
freezing of purified enzyme results in complete loss of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
Homo sapiens
3,3-Tetramethylene glutaric acid
-
Homo sapiens
Alrestatin 1,3-dioxo-1H-benz[de]isoquinoline-2-(3H)acetic acid Homo sapiens
Li2SO4 0.4 M: essential for full activity Homo sapiens
N-ethylmaleimide
-
Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens
Phenobarbital
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01 0.015 NADPH
-
Homo sapiens
0.011
-
propionaldehyde
-
Homo sapiens
0.039
-
Pyridine-3-aldehyde
-
Homo sapiens
0.51
-
glyceraldehyde
-
Homo sapiens
0.62
-
NADH
-
Homo sapiens
1.18
-
D-glucuronate
-
Homo sapiens
102
-
ribose
-
Homo sapiens
142
-
galactose
-
Homo sapiens
155
-
glucose
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Li2SO4 0.4 M: essential for full expression of enzyme activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32500
-
1 * 32500, SDS-PAGE in presence of urea and 2-mercaptoethanol Homo sapiens
34300
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-D-deoxygalactose + NADPH
-
Homo sapiens ?
-
?
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-ribose + NAD(P)H
-
Homo sapiens ribitol + NAD(P)+
-
r
propionaldehyde + NAD(P)H
-
Homo sapiens propanol + NAD(P)+
-
?
pyridine-3-aldehyde + NADPH + H+
-
Homo sapiens 3-pyridinemethanol + NADP+
-
r
pyridinecarboxaldehyde + NAD(P)H 2-, 3- and 4-pyridinecarboxaldehyde Homo sapiens pyridylmethanol + NAD(P)+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 32500, SDS-PAGE in presence of urea and 2-mercaptoethanol Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens