Literature summary for 1.1.1.206 extracted from

Draeger, B.
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism (2006), Phytochemistry, 67, 327-337.

Search for more literature for 1.1.1.206

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
0.0113	-	NADPH	-	Hyoscyamus niger
0.0415	-	NADP+	-	Hyoscyamus niger
0.058	-	NADPH	-	Datura stramonium
0.105	-	NADP+	-	Datura stramonium
0.775	-	tropinone	pH 5.9	Datura stramonium
1.01	-	tropinone	pH 5.9	Hyoscyamus niger
1.3	-	tropinone	pH 6.4	Datura stramonium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
tropinone + NADPH + H+	Datura stramonium	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	r
tropinone + NADPH + H+	Hyoscyamus niger	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	r
tropinone + NADPH + H+	Atropa belladonna	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	?
tropinone + NADPH + H+	Scopolia atropoides	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	?
tropinone + NADPH + H+	Hyoscyamus muticus	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	?
tropinone + NADPH + H+	Duboisia leichhardtii	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	?
tropinone + NADPH + H+	Duboisia myoporoides	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	tropine + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Atropa belladonna	-	-	-
Datura stramonium	-	-	-
Duboisia leichhardtii	-	-	-
Duboisia myoporoides	-	-	-
Hyoscyamus muticus	-	-	-
Hyoscyamus niger	-	-	-
Scopolia atropoides	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
3-methyl-cyclohexanone + NADPH	85% of the reaction velocity with tropinone	Hyoscyamus niger	3-methylcyclohexanol + NADP+	-	?
4-ethylcyclohexanone + NADPH	41% of the reaction velocity with tropinone	Datura stramonium	4-ethylcyclohexanol + NADP+	-	?
4-ethylcyclohexanone + NADPH	107% of the reaction velocity with tropinone	Hyoscyamus niger	4-ethylcyclohexanol + NADP+	-	?
4-tetrahydro-thiopyranone + NADPH	83% of the reaction velocity with tropinone	Datura stramonium	?	-	?
8-thiabicyclo[3.2.1]octan-3-one + NADPH	35% of the reaction velocity with tropinone	Datura stramonium	?	-	?
8-thiabicyclo[3.2.1]octan-3-one + NADPH	40% of the reaction velocity with tropinone	Hyoscyamus niger	?	-	?
additional information	no activity with 3-methyl-cyclohexanone	Datura stramonium	?	-	?
additional information	no activity with N-propyl-4-pieridinone and 4-tetrahydro-thiopyranone	Hyoscyamus niger	?	-	?
N-methyl-4-piperidinone + NADPH	180% of the reaction velocity with tropinone	Datura stramonium	N-methyl-1-piperidinol + NADP+	-	?
N-methyl-4-piperidinone + NADPH + H+	13% of the reaction velocity with tropinone	Hyoscyamus niger	N-methyl-1-piperidinol + NADP+	-	?
N-propyl-4-piperidinone + NADPH	78% of the reaction velocity with tropinone	Datura stramonium	N-propylpiperidinol + NADP+	-	?
quinuclidinone + NADPH	80% of the reaction velocity with tropinone	Datura stramonium	?	-	?
quinuclidinone + NADPH	136% of the reaction velocity with tropinone	Hyoscyamus niger	?	-	?
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Datura stramonium	tropine + NADP+	-	r
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Hyoscyamus niger	tropine + NADP+	-	r
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Atropa belladonna	tropine + NADP+	-	?
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Scopolia atropoides	tropine + NADP+	-	?
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Hyoscyamus muticus	tropine + NADP+	-	?
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Duboisia leichhardtii	tropine + NADP+	-	?
tropinone + NADPH + H+	tropine is the precursor of the tropane alkaloids hyoscyamine and scopolamine	Duboisia myoporoides	tropine + NADP+	-	?
tropinone + NADPH + H+	-	Datura stramonium	tropine + NADP+	-	r
tropinone + NADPH + H+	-	Hyoscyamus niger	tropine + NADP+	-	r
tropinone + NADPH + H+	-	Atropa belladonna	tropine + NADP+	-	?
tropinone + NADPH + H+	-	Scopolia atropoides	tropine + NADP+	-	?
tropinone + NADPH + H+	-	Hyoscyamus muticus	tropine + NADP+	-	?
tropinone + NADPH + H+	-	Duboisia leichhardtii	tropine + NADP+	-	?
tropinone + NADPH + H+	-	Duboisia myoporoides	tropine + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
TRI	-	Datura stramonium
TRI	-	Hyoscyamus niger
TRI	-	Atropa belladonna
TRI	-	Scopolia atropoides
TRI	-	Hyoscyamus muticus
TRI	-	Duboisia leichhardtii
TRI	-	Duboisia myoporoides
tropinone reductase	-	Datura stramonium
tropinone reductase	-	Hyoscyamus niger
tropinone reductase	-	Atropa belladonna
tropinone reductase	-	Scopolia atropoides
tropinone reductase	-	Hyoscyamus muticus
tropinone reductase	-	Duboisia leichhardtii
tropinone reductase	-	Duboisia myoporoides

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
25.6	-	tropinone	pH 7.0	Datura stramonium

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.1	-	reduction reaction	Hyoscyamus niger
6.4	-	reduction reaction	Datura stramonium
7.6	-	oxidation reaction	Hyoscyamus niger
9.9	-	oxidation reaction	Datura stramonium

Cofactor

Cofactor	Comment	Organism
NADPH	-	Datura stramonium
NADPH	-	Hyoscyamus niger
NADPH	-	Atropa belladonna
NADPH	-	Scopolia atropoides
NADPH	-	Hyoscyamus muticus
NADPH	-	Duboisia leichhardtii
NADPH	-	Duboisia myoporoides