Literature summary for 1.1.1.205 extracted from

Anthony, S.; Peterson, J.R.; Ji, Y.
Use of inosine monophosphate dehydrogenase activity assay to determine the specificity of PARP-1 inhibitors (2017), Methods Mol. Biol., 1608, 337-342 .

Search for more literature for 1.1.1.205

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[2-(cyclododecyloxy)-2-oxoethyl]-1-methylpiperidin-1-ium	i.e. 5F02, about 40% inhibition at 4 mM, less than 20% inhibition at 1 and 8 mM	Homo sapiens
olaparib	about 70% inhibition at 8 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
IMP + NAD+ + H2O	Homo sapiens	-	XMP + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA bead chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
IMP + NAD+ + H2O	-	Homo sapiens	XMP + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
IMPDH	-	Homo sapiens
inosine monophosphate dehydrogenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)