Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate | - |
Cryptosporidium parvum | |
(2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | Q21 | Bacillus anthracis | |
(2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | Q21 | Cryptosporidium parvum | |
(2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | Q21 | Listeria monocytogenes | |
(2S)-2-(2,3-dichloroanilino)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | Q67 | Mycobacterium tuberculosis | |
(2S)-N-(4-iodophenyl)-2-(4-methoxyphenoxy)propanamide | 7759844 | Mycolicibacterium thermoresistibile | |
(2S)-N-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-[4-(1-methyl-1H-imidazol-4-yl)phenoxy]propanamide | AT080 | Mycolicibacterium thermoresistibile | |
(5S)-7-amino-5-(4-chlorophenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile | F2K | Pseudomonas aeruginosa | |
2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(6,7,8,9-tetrahydrodibenzo[b,d]furan-2-yl)acetamide | D67 | Bacillus anthracis | |
2-chloro-5-[[(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)carbamoyl]amino]benzamide | P32 | Bacillus anthracis | |
2-chloro-N,N-dimethyl-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl[carbamoyl)amino]benzamide | P41 | Mycobacterium tuberculosis | |
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide | - |
Cryptosporidium parvum | |
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate | - |
Cryptosporidium parvum | |
3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide | P200 | Bacillus anthracis | |
3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide | P200 | Campylobacter jejuni | |
3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide | P200 | Clostridium perfringens | |
4-(4-bromophenyl)-1H-imidazole | NMR744 | Mycolicibacterium thermoresistibile | |
4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]quinolin-2(1H)-one | A110 | Bacillus anthracis | |
4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]quinolin-2(1H)-one | A110 | Clostridium perfringens | |
5'-O-([1-[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]-1H-1,2,3-triazol-4-yl[methyl)adenosine | MAD1, uncompetitive inhibitor | Mycobacterium tuberculosis | |
5-([[2-([1,1'-biphenyl]-3-yl)propan-2-yl]carbamoyl]amino)-2-chlorobenzamide | - |
Cryptosporidium parvum | |
cyclohexyl[4-(isoquinoline-5-sulfonyl)piperazin-1-yl]methanone | VCC234718 | Mycolicibacterium thermoresistibile | |
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate | - |
Cryptosporidium parvum | |
Mycophenolic acid | - |
Vibrio cholerae | |
N-(2-{3-[(1E)-N-(2-aminoethoxy)ethanimidoyl]phenyl}propan-2-yl)-N'-(4-chloro-3-nitrophenyl)urea | P131 | Cryptosporidium parvum | |
N-(2H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide | TBK6 | Mycobacterium tuberculosis | |
N-(2H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide | TBK6 | Mycolicibacterium thermoresistibile | |
N-(4-bromophenyl)-2-[2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]acetamide | - |
Cryptosporidium parvum | |
N-(4-bromophenyl)-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea | P68 | Bacillus anthracis | |
N-(4-bromophenyl)-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea | P12 | Campylobacter jejuni | |
N-(4-chloro-3-methoxyphenyl)-2-(4-oxo[1]benzopyrano[4,3-c]pyrazol-1(4H)-yl)acetamide | - |
Cryptosporidium parvum | |
N-(4-chlorophenyl)-2-phenoxypropanamide | - |
Cryptosporidium parvum | |
N-(4-fluorophenyl)-4-[(2H-indazol-6-yl)sulfamoyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide | - |
Mycolicibacterium thermoresistibile | |
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide | - |
Cryptosporidium parvum | |
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide | - |
Cryptosporidium parvum | |
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | - |
Cryptosporidium parvum | |
N-(naphthalen-2-yl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | - |
Cryptosporidium parvum | |
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | C91 | Bacillus anthracis | |
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | C91 | Campylobacter jejuni | |
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | C91 | Clostridium perfringens | |
N-naphthalen-2-yl-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea | - |
Cryptosporidium parvum | |
N-[(1R)-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethyl[-N'-phenylurea | G36 | Mycobacterium tuberculosis | |
N-[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-beta-D-xylofuranosylamine | P176; P221 | Bacillus anthracis | |
N-[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-beta-D-xylofuranosylamine | P176; P221 | Clostridium perfringens | |
N-[2-chloro-5-[([2-[3-(propan-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-?-D-ribofuranosylamine | P176 | Campylobacter jejuni | |
N-[4-chloro-3-(alpha-D-ribofuranosyloxy)phenyl]-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea | P178 | Bacillus anthracis | |
N-[4-chloro-3-(alpha-D-ribofuranosyloxy)phenyl]-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea | P178 | Clostridium perfringens | |
N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea | P182 | Bacillus anthracis | |
N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea | P182 | Campylobacter jejuni | |
N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea | P182 | Clostridium perfringens | |
oxanosine monophosphate | - |
Bacillus anthracis | |
[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenoxy]acetic acid | P225 | Campylobacter jejuni | |
[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenoxy]acetic acid | P225 | Clostridium perfringens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Cryptosporidium parvum | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Bacillus anthracis | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Pseudomonas aeruginosa | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Mycobacterium tuberculosis | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Campylobacter jejuni | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Mycolicibacterium thermoresistibile | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Clostridium perfringens | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Vibrio cholerae | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Listeria monocytogenes | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Bacillus anthracis Ames | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Mycolicibacterium thermoresistibile ATCC 19527 | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Listeria monocytogenes ATCC BAA-679 | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Mycobacterium tuberculosis H37Rv | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Vibrio cholerae ATCC 39315 | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Bacillus anthracis | A0A6L8P2U9 | - |
- |
Bacillus anthracis Ames | - |
- |
- |
Campylobacter jejuni | A0A2R4D3F6 | - |
- |
Clostridium perfringens | A0A127ELD1 | - |
- |
Cryptosporidium parvum | - |
- |
- |
Listeria monocytogenes | Q926Y9 | - |
- |
Listeria monocytogenes ATCC BAA-679 | Q926Y9 | - |
- |
Mycobacterium tuberculosis | P9WKI7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WKI7 | - |
- |
Mycolicibacterium thermoresistibile | G7CNL4 | - |
- |
Mycolicibacterium thermoresistibile ATCC 19527 | G7CNL4 | - |
- |
Pseudomonas aeruginosa | Q9HXM5 | - |
- |
Vibrio cholerae | Q9KTW3 | - |
- |
Vibrio cholerae ATCC 39315 | Q9KTW3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Cryptosporidium parvum | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Bacillus anthracis | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Pseudomonas aeruginosa | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Mycobacterium tuberculosis | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Campylobacter jejuni | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Mycolicibacterium thermoresistibile | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Clostridium perfringens | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Vibrio cholerae | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Listeria monocytogenes | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Bacillus anthracis Ames | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Mycolicibacterium thermoresistibile ATCC 19527 | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Listeria monocytogenes ATCC BAA-679 | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Mycobacterium tuberculosis H37Rv | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Vibrio cholerae ATCC 39315 | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guaB2 | - |
Mycobacterium tuberculosis |
IMPDH | - |
Cryptosporidium parvum |
IMPDH | - |
Bacillus anthracis |
IMPDH | - |
Pseudomonas aeruginosa |
IMPDH | - |
Mycobacterium tuberculosis |
IMPDH | - |
Campylobacter jejuni |
IMPDH | - |
Mycolicibacterium thermoresistibile |
IMPDH | - |
Clostridium perfringens |
IMPDH | - |
Vibrio cholerae |
IMPDH | - |
Listeria monocytogenes |
inosine 5'-monophosphate dehydrogenase | - |
Cryptosporidium parvum |
inosine 5'-monophosphate dehydrogenase | - |
Bacillus anthracis |
inosine 5'-monophosphate dehydrogenase | - |
Pseudomonas aeruginosa |
inosine 5'-monophosphate dehydrogenase | - |
Mycobacterium tuberculosis |
inosine 5'-monophosphate dehydrogenase | - |
Campylobacter jejuni |
inosine 5'-monophosphate dehydrogenase | - |
Mycolicibacterium thermoresistibile |
inosine 5'-monophosphate dehydrogenase | - |
Clostridium perfringens |
inosine 5'-monophosphate dehydrogenase | - |
Vibrio cholerae |
inosine 5'-monophosphate dehydrogenase | - |
Listeria monocytogenes |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Cryptosporidium parvum | |
NAD+ | - |
Bacillus anthracis | |
NAD+ | - |
Pseudomonas aeruginosa | |
NAD+ | - |
Mycobacterium tuberculosis | |
NAD+ | - |
Campylobacter jejuni | |
NAD+ | - |
Mycolicibacterium thermoresistibile | |
NAD+ | - |
Clostridium perfringens | |
NAD+ | - |
Vibrio cholerae | |
NAD+ | - |
Listeria monocytogenes |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000021 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | N-naphthalen-2-yl-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea | |
0.000004 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | 5-([[2-([1,1'-biphenyl]-3-yl)propan-2-yl]carbamoyl]amino)-2-chlorobenzamide | |
0.0001 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | (1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate | |
0.0009 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | 3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate | |
0.0012 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | |
0.0014 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | 2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide | |
0.0016 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate | |
0.0016 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide | |
0.0033 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | N-(4-chlorophenyl)-2-phenoxypropanamide | |
0.0054 | - |
pH and temperature not specified in the publication | Cryptosporidium parvum | N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide |