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Literature summary for 1.1.1.205 extracted from

  • Huang, F.; Ni, M.; Chalishazar, M.D.; Huffman, K.E.; Kim, J.; Cai, L.; Shi, X.; Cai, F.; Zacharias, L.G.; Ireland, A.S.; Li, K.; Gu, W.; Kaushik, A.K.; Liu, X.; Gazdar, A.F.; Oliver, T.G.; Minna, J.D.; Hu, Z.; DeBerardinis, R.J.
    Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers (2018), Cell Metab., 28, 369-382.e5 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Homo sapiens
-
 XMP + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P12268
-
-
Homo sapiens P20839
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCC-33 cell
-
 Homo sapiens
-
NCI-H1522 cell
-
 Homo sapiens
-
NCI-H1628 cell
-
 Homo sapiens
-
NCI-H1672 cell
-
 Homo sapiens
-
NCI-H1836 cell
-
 Homo sapiens
-
NCI-H2029 cell
-
 Homo sapiens
-
NCI-H211 cell
-
 Homo sapiens
-
NCI-H2141 cell
-
 Homo sapiens
-
NCI-H2171 cell
-
 Homo sapiens
-
NCI-H3282 cell
-
 Homo sapiens
-
NCI-H524 cell
-
 Homo sapiens
-
NCI-H526 cell
-
 Homo sapiens
-
NCI-H60 cell
-
 Homo sapiens
-
NCI-H82 cell
-
 Homo sapiens
-
small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Homo sapiens XMP + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
IMPDH1 isoform Homo sapiens
IMPDH2 isoform Homo sapiens
inosine monophosphate dehydrogenase-1
-
 Homo sapiens
inosine monophosphate dehydrogenase-2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme selectively inhibits cell and tumor growth of ASCL1Low small cell lung cancer cells Homo sapiens