Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mycophenolic acid | - |
Homo sapiens | |
ribavirin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Homo sapiens | - |
XMP + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12268 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
HEP-3B cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Homo sapiens | XMP + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
IMP dehydrogenase | - |
Homo sapiens |
IMPDH | - |
Homo sapiens |
IMPDH2 | - |
Homo sapiens |
inosine monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | siRNA knockdown of serine hydroxymethyltransferase-2, SHMT2, or dihydrofolate reductase, DHFR, leads to increased rod and ring (RR) formation. IMPDH-containing RR structures can form in mammalian cells | Homo sapiens |
physiological function | inosine monophosphate dehydrogenase (IMPDH), a key enzyme leading to GMP and GTP biosynthesis. Rod and ring (RR) formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. RR formation is induced by IMPDH inhibitors as well as glutamine deprivation. Because RR assembly occurs when guanine nucleotide biosynthesis is inhibited, and because RRs rapidly disassemble after the addition of guanine nucleotide precursors, RR formation might be an adaptive homeostatic mechanism, allowing IMPDH to sense changes in the one-carbon folate pathway, detailed overview | Homo sapiens |