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Literature summary for 1.1.1.205 extracted from

  • Dairaku, I.; Han, Y.; Yanaka, N.; Kato, N.
    Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents (2010), Biosci. Biotechnol. Biochem., 74, 185-187.
    View publication on PubMed
Search for more literature for 1.1.1.205

Cloned(Commentary)

Cloned (Comment) Organism
isoform IMPDH2, expression in Escherichia coli Homo sapiens
isoform IMPDH2, expression in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
chlorogenic acid 0.1 mM, 30% inhibition Mus musculus
curcumin significantly reduces the level of GTP and reduces the rate of cell growth Homo sapiens
curcumin 0.1 mM, 68% inhibition, both competitive and uncompetitive Mus musculus
ellagic acid 0.1 mM, 27% inhibition Mus musculus
epigallocatechin gallate 0.1 mM, 47% inhibition Mus musculus
additional information not inhibitory: resveratrol, genistein, eugenol, gingerol, naringenin, naringin, caffeic acid, morin, kaempferol, hesperidin, rosmarinic acid Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0509
-
 inosine 5'-phosphate pH not specified in the publication, temperature not specified in the publication Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus P24547 IMPDH2
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+
-
 Mus musculus xanthosine 5'-phosphate + NADH + H+
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0997
-
 curcumin pH not specified in the publication, temperature not specified in the publication Mus musculus