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Literature summary for 1.1.1.205 extracted from

  • Chen, L.; Wilson, D.; Jayaram, H.N.; Pankiewicz, K.W.
    Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment (2007), J. Med. Chem., 50, 6685-6691.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(5E)-N-hydroxy-7-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-5-methylhept-5-enamide comparison with inhibition of histone deacetylase and K562 cell proliferation Homo sapiens
Mycophenolic acid comparison with inhibition of histone deacetylase and K562 cell proliferation Homo sapiens
mycophenolic hydroxamic acid comparison with inhibition of histone deacetylase and K562 cell proliferation Homo sapiens
N-hydroxy-N'-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]octanediamide comparison with inhibition of histone deacetylase and K562 cell proliferation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00001
-
Mycophenolic acid isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.00003
-
mycophenolic hydroxamic acid isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.00004
-
Mycophenolic acid isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.00007
-
mycophenolic hydroxamic acid isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.0004
-
(5E)-N-hydroxy-7-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-5-methylhept-5-enamide isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.0011
-
(5E)-N-hydroxy-7-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-5-methylhept-5-enamide isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.0017
-
N-hydroxy-N'-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]octanediamide isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.005
-
N-hydroxy-N'-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]octanediamide isoform IMPDH1, pH 8.0, 25°C Homo sapiens